Association of Neutrophil-Lymphocyte Ratio and Red Blood Cell Distribution Width with Poor Outcome in Pediatric Cardiac Surgery - A Retrospective Observational Study.

IF 1.1 Q3 ANESTHESIOLOGY
Annals of Cardiac Anaesthesia Pub Date : 2024-07-01 Epub Date: 2024-07-04 DOI:10.4103/aca.aca_9_24
Alok Kumar, Monika Aggarwal, Akash Mohapatra, Nihar Ameta
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引用次数: 0

Abstract

Background: Neutrophil-lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammatory response and red blood cell distribution width (RBDW), a routinely available biomarker of likely erythropoietic dysfunction, which may be associated with adverse outcomes after cardiac surgery. This study aimed to investigate the association between these two readily available haematological parameters, with the poor outcomes in paediatric patients undergoing cardiac surgery.

Methods: A comprehensive review of medical records for paediatric patients who underwent cardiac surgery at our tertiary care centre between April 2022 and June 2023 was carried out. RBDW and NLR values were collected from complete blood count reports obtained on admission to the ICU. Demographic data, surgical details, and postoperative complications were also recorded. A receiver operating characteristic (ROC) curve and multivariable logistic regression were applied to identify the prognosis performance of preoperative NLR and RBDW for poor outcomes.

Results: The study included 219 patients meeting the inclusion criteria of which a total of 90 (41%) children experienced at least one of the poor outcomes. Preoperative NLR (AUC=0.88, 95%CI 0.36-0.70, cut off- 4.2) and RBDW (AUC=0.88, 95%CI 0.39-0.73, cut off- 18.5%) showed prognostic significance in the perioperative period.

Conclusion: This retrospective observational study highlights a significant association between elevated Red Blood Cell Distribution Width (RBDW) and Neutrophil Lymphocyte Ratio (NLR) values and poor outcomes in paediatric patients undergoing cardiac surgery. These readily available haematological parameters could serve as potential prognostic indicators for identifying patients at risk of poor outcomes.

中性粒细胞-淋巴细胞比率和红细胞分布宽度与小儿心脏手术不良预后的关系--一项回顾性观察研究。
背景:中性粒细胞-淋巴细胞比值(NLR)是评估炎症反应的重要指标,而红细胞分布宽度(RBDW)是红细胞生成功能障碍的常规生物标志物,可能与心脏手术后的不良预后有关。本研究旨在调查这两个现成的血液学参数与接受心脏手术的儿科患者不良预后之间的关系:方法:对 2022 年 4 月至 2023 年 6 月期间在我们的三级医疗中心接受心脏手术的儿科患者的病历进行了全面审查。RBDW和NLR值是从重症监护室入院时获得的全血细胞计数报告中收集的。此外,还记录了人口统计学数据、手术细节和术后并发症。应用接收器操作特征曲线(ROC)和多变量逻辑回归确定术前 NLR 和 RBDW 对不良预后的影响:研究共纳入219名符合纳入标准的患者,其中90名(41%)患儿至少出现一种不良预后。术前NLR(AUC=0.88,95%CI 0.36-0.70,切点4.2)和RBDW(AUC=0.88,95%CI 0.39-0.73,切点18.5%)在围手术期显示出预后意义:这项回顾性观察研究强调了红细胞分布宽度(RBDW)和中性粒细胞淋巴细胞比值(NLR)升高与接受心脏手术的儿科患者不良预后之间的显著关联。这些现成的血液学参数可作为潜在的预后指标,用于识别有不良预后风险的患者。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
147
审稿时长
26 weeks
期刊介绍: Annals of Cardiac Anaesthesia (ACA) is the official journal of the Indian Association of Cardiovascular Thoracic Anaesthesiologists. The journal is indexed with PubMed/MEDLINE, Excerpta Medica/EMBASE, IndMed and MedInd. The journal’s full text is online at www.annals.in. With the aim of faster and better dissemination of knowledge, we will be publishing articles ‘Ahead of Print’ immediately on acceptance. In addition, the journal would allow free access (Open Access) to its contents, which is likely to attract more readers and citations to articles published in ACA. Authors do not have to pay for submission, processing or publication of articles in ACA.
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