Efficacy and safety analysis of anlotinib in combination with immune checkpoint inhibitors for second-line and subsequent extensive-stage small-cell lung cancer.

IF 2 4区 医学 Q3 ONCOLOGY
Xixi Ying, Zheng Shi, Rongjun Shao, Guangxian You, Zhengbo Song
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Abstract

Currently, there is a lack of effective second-line and subsequent treatments for patients with extensive-stage small-cell lung cancer (ES-SCLC), and the establishment of a standardized treatment protocol is still underway. Considering the potential synergistic therapeutic effects of anti-angiogenic drugs and immune checkpoint inhibitors (ICIs), combination therapy could be a viable option for treating lung cancer. This research concentrates on assessing the efficacy and safety of anlotinib in combination with ICIs for the treatment of ES-SCLC. We undertook a retrospective analysis of patients with extensive-stage SCLC who received anlotinib in combination with ICIs as second-line and subsequent treatment at Zhejiang Cancer Hospital between April 2020 and April 2023. Survival rates were analyzed using the Kaplan-Meier method. Among the 43 patients who received combination therapy, there were no cases of complete response (CR), 16 patients who achieved partial response (PR), 21 patients who had stable disease (SD), and 6 patients who experienced disease progression (PD). This resulted in an overall response rate (ORR) of 37.2% (16/43) and a disease control rate (DCR) of 86.0% (34/43). The median progression-free survival (PFS) was 4.0 months (95% CI: 2.74-5.26), and the median overall survival (OS) time was 10 months (95% CI: 4.8-15.2). Cox multifactorial regression analysis disclosed that the performance score (PS) and the number of metastatic organs were independent factors influencing PFS in ES-SCLC (p<0.001). The combination therapy demonstrated acceptable toxicity, with a total grade 3/4 toxicity rate of 30.2%. The combination therapy showed a notable association with several adverse events, including hand-foot syndrome, hypertension, and fatigue, which were the most significant. Combining anlotinib with immune checkpoint inhibitors has demonstrated favorable efficacy and safety in the treatment of second-line and subsequent extensive-stage small-cell lung cancer.

安罗替尼联合免疫检查点抑制剂治疗二线及后续广泛期小细胞肺癌的疗效和安全性分析。
目前,广泛期小细胞肺癌(ES-SCLC)患者缺乏有效的二线治疗和后续治疗方法,标准化治疗方案的建立仍在进行中。考虑到抗血管生成药物和免疫检查点抑制剂(ICIs)的潜在协同治疗效果,联合疗法可能是治疗肺癌的一种可行选择。本研究主要评估安罗替尼联合 ICIs 治疗 ES-SCLC 的有效性和安全性。我们对2020年4月至2023年4月期间在浙江省肿瘤医院接受安罗替尼联合ICIs二线及后续治疗的广泛期SCLC患者进行了回顾性分析。生存率采用卡普兰-梅耶法进行分析。在接受联合治疗的43例患者中,没有完全应答(CR)病例,16例患者获得部分应答(PR),21例患者病情稳定(SD),6例患者病情进展(PD)。总反应率(ORR)为 37.2%(16/43),疾病控制率(DCR)为 86.0%(34/43)。中位无进展生存期(PFS)为4.0个月(95% CI:2.74-5.26),中位总生存期(OS)为10个月(95% CI:4.8-15.2)。Cox多因素回归分析显示,表现评分(PS)和转移器官数量是影响ES-SCLC患者PFS的独立因素(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neoplasma
Neoplasma 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
238
审稿时长
3 months
期刊介绍: The journal Neoplasma publishes articles on experimental and clinical oncology and cancer epidemiology.
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