A Prospective, Multicenter, Evaluator-Blinded, Randomized Study of Diluted Calcium Hydroxylapatite to Treat Decollete Wrinkles.

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of Drugs in Dermatology Pub Date : 2024-07-01 DOI:10.36849/JDD.8261

Tatjana Pavicic, Martina Kerscher, Ulrich Kuhne, Iryna Heide, Hanna Dersch, Gemma Odena, Virginia Graul

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引用次数: 0

Abstract

Background: Calcium hydroxylapatite (CaHA) dermal filler is used for a variety of aesthetic treatments; however, the safety and effectiveness of diluted CaHA for the treatment of décolleté wrinkles have not been established.

Objective: To demonstrate the effectiveness and safety of diluted CaHA (Radiesse; 1:2 CaHA:saline) injection for the improvement of décolleté wrinkles in females.

Methods: Eligible females with moderate or severe ratings on the Merz Aesthetic Scale (MAS) Decollete Wrinkles - At Rest received up to 3 injection cycles of diluted CaHA either 8 weeks apart (3 injection cycles) or 16 weeks apart (2 injection cycles). Effectiveness was evaluated by improvement on the MAS. Adverse events were recorded over a 52 week period.

Results: Sixteen weeks after the last treatment, the response rate (1-point improvement or greater) on the MAS Decollete Wrinkles - At Rest was 73.5% (P<0.0001; pooled sample) for all patients. The use of diluted CaHA in the decollete also demonstrated a favorable safety profile.

Conclusions: Diluted CaHA is a safe and effective treatment for the improvement of decollete wrinkles in females.J Drugs Dermatol. 2024;23(7):551-556. doi:10.36849/JDD.8261.

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稀释羟磷灰石钙治疗法令纹的前瞻性、多中心、评估者对照随机研究

背景：羟基磷灰石钙（CaHA）皮肤填充剂被用于多种美容治疗；然而，稀释的CaHA用于治疗décolleté皱纹的安全性和有效性尚未确定：证明稀释 CaHA（Radiesse；1:2 CaHA:生理盐水）注射用于改善女性 décolleté 皱纹的有效性和安全性：符合条件的女性在默氏美学量表（MERZ Aesthetic Scale，MAS）"肩部皱纹--静止时 "评分中被评为中度或重度，接受最多 3 个稀释 CaHA 注射周期的治疗，间隔时间为 8 周（3 个注射周期）或 16 周（2 个注射周期）。疗效根据 MAS 的改善情况进行评估。在 52 周内记录不良事件：最后一次治疗 16 周后，所有患者的 MAS 十周皱纹--静止时的反应率（改善 1 点或更多）为 73.5%（P<0.0001；汇总样本）。在十指皱纹中使用稀释的 CaHA 还显示出良好的安全性：稀释的 CaHA 是改善女性法令纹的一种安全有效的治疗方法。2024;23(7):551-556. doi:10.36849/JDD.8261.

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来源期刊

Journal of Drugs in Dermatology DERMATOLOGY-

CiteScore

2.20

自引率

13.30%

发文量

289

审稿时长

3-6 weeks

期刊介绍： The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.