Tumor and cancer stem cells-derived exosomes interplay: A secret of cancer complications

Clinical and translational discovery Pub Date : 2024-06-27 DOI:10.1002/ctd2.325

Swarup Sonar, Sidhanti Nyahatkar, Ketki Kalele

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Abstract

Cancer stem cells (CSCs) are a small subset of tumor cells, efficient in self-renewal within the tumor and also play a vital role in cancer resistance and metastasis. Recent cancer research has focused on exosomes, a tiny subpopulation of extracellular vesicles (EVs), known for their role in intercellular communication, and significantly contributing to tumor development and metastasis (Tumor derived exosomes-TEXs). These exosomes complicate cancer treatment by promoting tumor and CSC formation and developing drug and therapeutic resistance. This article explores how tumor-derived exosomes impact CSC survival, proliferation, and resistance to therapies, leading to tumor recurrence. In a tumor microenvironment (TME), exosomes facilitate tumor growth and metastasis. Targeting exosomes could disrupt CSC communication and improve cancer treatment efficacy. Current studies highlight the role of CSCs exosomes in cancer progression and therapeutic resistance. Understanding CSCs exosome-based cell-to-cell communication in tumor opens a new horizon in cancer therapeutics development.

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肿瘤和癌症干细胞衍生的外泌体相互作用：癌症并发症的秘密

癌症干细胞（CSCs）是肿瘤细胞中的一小部分，能在肿瘤内高效地自我更新，在癌症抗药性和转移方面也发挥着重要作用。外泌体是细胞外囊泡（EVs）的一个极小亚群，因其在细胞间通信中的作用而闻名，并对肿瘤的发展和转移起着重要作用（肿瘤衍生外泌体-TEXs）。这些外泌体可促进肿瘤和癌细胞间充质干细胞的形成，并产生耐药性和抗药性，从而使癌症治疗复杂化。本文探讨了肿瘤衍生外泌体如何影响 CSC 的生存、增殖和对疗法的耐受性，从而导致肿瘤复发。在肿瘤微环境（TME）中，外泌体有助于肿瘤生长和转移。以外泌体为靶点可以破坏癌细胞间的交流，提高癌症治疗效果。目前的研究强调了干细胞外泌体在癌症进展和治疗耐药性中的作用。了解肿瘤中基于外泌体的细胞间通讯为癌症疗法的开发开辟了新天地。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and translational discovery

CiteScore

1.00

自引率

0.00%

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