Zilong Song , Shixin Xu , Robert Eisenberg , Huaxiong Huang
{"title":"A multi-domain model for microcirculation in optic nerve: Blood flow and oxygen transport","authors":"Zilong Song , Shixin Xu , Robert Eisenberg , Huaxiong Huang","doi":"10.1016/j.physd.2024.134272","DOIUrl":null,"url":null,"abstract":"<div><p>Microcirculation of blood and transport of oxygen play important roles in the biological function of the optic nerve and its diseases. This work develops a multi-domain model for the optic nerve, that includes important biological structures and various physical mechanisms in blood flow and oxygen delivery. The two vascular networks are treated as five domains in the same geometric region, with various exchanges among them (such as Darcy’s law for fluid flow) and with the tissue domain (such as water leak, diffusion). The numerical results of the coupled model for a uniform case of vasculature distribution show mechanisms and scales consistent with literature and intuition. The effects of various important model parameters (relevant to pathological conditions) are investigated to provide insights into the possible implications. The vasculature distribution (resting volume fractions here) has significant impacts on the blood circulation and could lead to insufficient blood supply in certain local regions and thereby affect the delivery of oxygen. The water leak across the capillary wall will have nontrivial effects after the leak coefficients pass a threshold. The pulsatile arterial pressure leads to expected pulsatile patterns and stable spatial profiles, and the uniform case is almost the averaged version of pulsatile case. The effects of viscosity, the stiffness of blood vessel wall, oxygen demand, etc. have also been analyzed. The framework can be extended to include ionic transport or to study the retina when more biological structural information is available.</p></div>","PeriodicalId":20050,"journal":{"name":"Physica D: Nonlinear Phenomena","volume":"467 ","pages":"Article 134272"},"PeriodicalIF":2.7000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica D: Nonlinear Phenomena","FirstCategoryId":"100","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167278924002239","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATHEMATICS, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Microcirculation of blood and transport of oxygen play important roles in the biological function of the optic nerve and its diseases. This work develops a multi-domain model for the optic nerve, that includes important biological structures and various physical mechanisms in blood flow and oxygen delivery. The two vascular networks are treated as five domains in the same geometric region, with various exchanges among them (such as Darcy’s law for fluid flow) and with the tissue domain (such as water leak, diffusion). The numerical results of the coupled model for a uniform case of vasculature distribution show mechanisms and scales consistent with literature and intuition. The effects of various important model parameters (relevant to pathological conditions) are investigated to provide insights into the possible implications. The vasculature distribution (resting volume fractions here) has significant impacts on the blood circulation and could lead to insufficient blood supply in certain local regions and thereby affect the delivery of oxygen. The water leak across the capillary wall will have nontrivial effects after the leak coefficients pass a threshold. The pulsatile arterial pressure leads to expected pulsatile patterns and stable spatial profiles, and the uniform case is almost the averaged version of pulsatile case. The effects of viscosity, the stiffness of blood vessel wall, oxygen demand, etc. have also been analyzed. The framework can be extended to include ionic transport or to study the retina when more biological structural information is available.
期刊介绍:
Physica D (Nonlinear Phenomena) publishes research and review articles reporting on experimental and theoretical works, techniques and ideas that advance the understanding of nonlinear phenomena. Topics encompass wave motion in physical, chemical and biological systems; physical or biological phenomena governed by nonlinear field equations, including hydrodynamics and turbulence; pattern formation and cooperative phenomena; instability, bifurcations, chaos, and space-time disorder; integrable/Hamiltonian systems; asymptotic analysis and, more generally, mathematical methods for nonlinear systems.