{"title":"Microfurnace or filament pyrolyzer: an example of pyrolysis-GC/MS for condom lubricant analysis","authors":"Céline Burnier , Jonathan Maurer","doi":"10.1016/j.forc.2024.100593","DOIUrl":null,"url":null,"abstract":"<div><p>Condom lubricants have been shown to contain polydimethylsiloxane (PDMS) in over 95% of cases, but PDMS is difficult to analyze using standard GC–MS or LC-MS due to their size, apolarity and issues with solvents and plasticizers. Py-GC–MS was established as one of the more relevant analytical techniques for PDMS evidence analysis. However, different pyrolysis units and various GC columns are available for use Py-GC–MS. These two parameters are likely to significantly affect the repeatability, reproducibility and sensitivity of the analysis and, as such, affect the recovery of condom traces in casework. This work employed a resistively heated filament pyrolyzer and an isothermal oven pyrolyzer to investigate differences in the profiles generated by the pyrolysis units in the analysis of 4 condom lubricants. Similar experiments were performed using different columns, with the same pyrolyzers, to determine which gave optimal compound separation. This enabled assessment of the combinations in terms of the qualitative and semi-quantitative repeatability, allowing recommendations for optimized condom residue analysis. Results indicate that the use of a HP-5MS column, coupled to an isothermal oven pyrolyzer, is the optimal instrument configuration for condom residue analysis, based on repeatability, reproducibility and sensitivity of PDMS analysis.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"40 ","pages":"Article 100593"},"PeriodicalIF":2.6000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468170924000456/pdfft?md5=9ccb1ff0cb73bcd6eb921af443ccf27e&pid=1-s2.0-S2468170924000456-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forensic Chemistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468170924000456","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Condom lubricants have been shown to contain polydimethylsiloxane (PDMS) in over 95% of cases, but PDMS is difficult to analyze using standard GC–MS or LC-MS due to their size, apolarity and issues with solvents and plasticizers. Py-GC–MS was established as one of the more relevant analytical techniques for PDMS evidence analysis. However, different pyrolysis units and various GC columns are available for use Py-GC–MS. These two parameters are likely to significantly affect the repeatability, reproducibility and sensitivity of the analysis and, as such, affect the recovery of condom traces in casework. This work employed a resistively heated filament pyrolyzer and an isothermal oven pyrolyzer to investigate differences in the profiles generated by the pyrolysis units in the analysis of 4 condom lubricants. Similar experiments were performed using different columns, with the same pyrolyzers, to determine which gave optimal compound separation. This enabled assessment of the combinations in terms of the qualitative and semi-quantitative repeatability, allowing recommendations for optimized condom residue analysis. Results indicate that the use of a HP-5MS column, coupled to an isothermal oven pyrolyzer, is the optimal instrument configuration for condom residue analysis, based on repeatability, reproducibility and sensitivity of PDMS analysis.
期刊介绍：
Forensic Chemistry publishes high quality manuscripts focusing on the theory, research and application of any chemical science to forensic analysis. The scope of the journal includes fundamental advancements that result in a better understanding of the evidentiary significance derived from the physical and chemical analysis of materials. The scope of Forensic Chemistry will also include the application and or development of any molecular and atomic spectrochemical technique, electrochemical techniques, sensors, surface characterization techniques, mass spectrometry, nuclear magnetic resonance, chemometrics and statistics, and separation sciences (e.g. chromatography) that provide insight into the forensic analysis of materials. Evidential topics of interest to the journal include, but are not limited to, fingerprint analysis, drug analysis, ignitable liquid residue analysis, explosives detection and analysis, the characterization and comparison of trace evidence (glass, fibers, paints and polymers, tapes, soils and other materials), ink and paper analysis, gunshot residue analysis, synthetic pathways for drugs, toxicology and the analysis and chemistry associated with the components of fingermarks. The journal is particularly interested in receiving manuscripts that report advances in the forensic interpretation of chemical evidence. Technology Readiness Level: When submitting an article to Forensic Chemistry, all authors will be asked to self-assign a Technology Readiness Level (TRL) to their article. The purpose of the TRL system is to help readers understand the level of maturity of an idea or method, to help track the evolution of readiness of a given technique or method, and to help filter published articles by the expected ease of implementation in an operation setting within a crime lab.
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