Reproductive factors, genetic susceptibility and risk of type 2 diabetes: A prospective cohort study

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2024-06-29 DOI:10.1016/j.diabet.2024.101560

Gaojie Fan, Qing Liu, Jianing Bi, Xiya Qin, Qing Fang, Fei Luo, Xiaofeng Huang, Heng Li, Youjie Wang, Lulu Song

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引用次数: 0

Abstract

Aim

To explore the relationships of multiple reproductive factors with type 2 diabetes mellitus (T2DM) risk and the joint effects of reproductive factors and genetic susceptibility.

Methods

We included 262,368 women without prevalent T2DM from the UK biobank. Cox proportional hazards regression models were employed to estimate the relationships of reproductive factors with T2DM risk and the joint effects of reproductive factors and genetic susceptibility.

Results

During a mean follow-up of 12.2 years, 8,996 T2DM cases were identified. Early menarche (<12 years, hazard ratio (HR) 1.08 [95 % confidence interval (CI) 1.02;1.13]), late menarche (≥15 years, HR 1.11 [1.04;1.17]), early menopause (<45 years, HR 1.20 [1.12;1.29]), short reproductive lifespan (<30 years, HR 1.25 [1.16;1.35]), hysterectomy (1.31, HR [1.23;1.40]), oophorectomy (HR 1.28 [1.20;1.36]), high parity (≥4, HR 1.25 [1.17;1.34]), early age at first live birth (<20 years, HR 1.23 [1.16;1.31]), miscarriage (HR 1.13 [1.07;1.19]), stillbirth (HR 1.14 [1.03;1.27]), and ever used hormonal replacement therapy (HR 1.19 [1.14;1.24]) were related to a higher T2DM risk, while ever used oral contraceptives (HR 0.93 [0.89;0.98]) was related to a lower T2DM risk. Furthermore, women with reproductive risk factors and high genetic risk had the highest T2DM risk compared to those with low genetic risk and without reproductive risk factors.

Conclusion

Our findings show that multiple reproductive factors are related to T2DM risk, particularly in women with high genetic risk.

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生殖因素、遗传易感性和 2 型糖尿病风险：一项前瞻性队列研究。

目的：探讨多种生殖因素与 2 型糖尿病（T2DM）风险的关系，以及生殖因素和遗传易感性的共同影响：我们从英国生物库中纳入了 262,368 名未患 T2DM 的女性。采用 Cox 比例危险度回归模型来估计生殖因素与 T2DM 风险的关系，以及生殖因素和遗传易感性的共同影响：结果：在平均 12.2 年的随访期间，共发现 8996 例 T2DM 病例。初潮早（< 12 岁，危险比 (HR) 1.08 [95% 置信区间 (CI) 1.02;1.13]）、初潮晚（≥ 15 岁，HR 1.11 [1.04;1.17]）、绝经早（< 45 岁，HR 1.20 [1.12;1.29]）、生育期短（< 30 年，HR 1.25 [1.16;1.35]）、子宫切除术（1.31，HR [1.23;1.40]）、输卵管切除术（HR 1.28 [1.20;1.36]）、高奇数（≥ 4，HR 1.25 [1.17;1.34]）、首次活产年龄早（< 20 岁，HR 1.23 [1.16;1.31]）、流产（HR 1.13 [1.07;1.19]）、死胎（HR 1.14 [1.03;1.27]）和曾使用激素替代疗法（HR 1.19 [1.14；1.24]）与较高的 T2DM 风险有关，而曾使用口服避孕药（HR 0.93 [0.89；0.98]）与较低的 T2DM 风险有关。此外，与低遗传风险和无生殖风险因素的妇女相比，具有生殖风险因素和高遗传风险的妇女患 T2DM 的风险最高：我们的研究结果表明，多种生殖因素与 T2DM 风险有关，尤其是遗传风险高的妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.