Bone Turnover Markers and Wnt Signaling Modulators in Early Complex Regional Pain Syndrome. A Pre-specified Observational Study.

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI:10.1007/s00223-024-01251-y
Massimo Varenna, Francesco Orsini, Raffaele Di Taranto, Francesca Zucchi, Giovanni Adami, Davide Gatti, Chiara Crotti
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引用次数: 0

Abstract

To explore serum levels of some bone turnover markers and the involvement of the Wnt signaling in CRPS-1. Query ID="Q1" Text="Please check and confirm whether the edit made to the article title is in order." We conducted an observational study on patients with early CRPS-1 recruited before any treatment. Clinical measures were assessed together with biochemical evaluation. Values of sclerostin, DKK1, CTX-I, and P1NP were compared with sex-age-matched healthy controls (HCs). We enrolled 34 patients diagnosed with CRPS-1 (mean age 59.3 ± 10.6 years, Male/Female 10/24), median disease duration = 2 weeks (IQR 1-5); median VAS score = 76 (IQR 68-80). Foot localization was slightly more frequent than hand localization (18/16). No statistically significant difference was found between CRPS-1 patients and HCs for CTX-I (0.3 ± 0.1 ng/ml vs 0.3 ± 0.1, p = 0.140), while mean serum values of P1NP were significantly higher in CRPS-1 patients compared to HCs (70.0 ± 38.8 ng/ml vs 50.1 ± 13.6, p = 0.005). Mean levels of sclerostin and DKK1 were lower in CRPS-1 patients vs HCs (sclerostin 28.4 ± 10.8 pmol/l vs 34.1 ± 11.6, p = 0.004; DKK1 12.9 ± 10.8 pmol/l vs 24.1 ± 11.9, p = 0.001). No statistically significant difference was found for all biochemical assessments in a subgroup of fracture-induced CRPS-1. No statistically significant differences were observed according to disease localization, disease duration, presence of hyperalgesia, allodynia, sudomotor alterations, and mild or moderate/severe swelling. No significant correlation emerged between sclerostin, DKK1 levels, baseline VAS score, or McGill Pain Questionnaire score. Bone involvement in early CRPS-1 does not seem to rely on increased osteoclast activity. Conversely, a serum marker of bone formation resulted increased. Both Sclerostin and DKK1 showed decreased values, probably suggesting a widespread osteocyte loss of function.Trial registration number: Eudract Number: 2014-001156-28.

Abstract Image

早期复杂性区域疼痛综合征的骨转换标志物和 Wnt 信号调节剂。一项预先指定的观察性研究。
探讨血清中某些骨转换标志物的水平以及Wnt信号转导在CRPS-1中的参与。Query ID="Q1" Text="请检查并确认对文章标题的编辑是否正确"。我们对治疗前招募的早期CRPS-1患者进行了一项观察性研究。在评估临床指标的同时还进行了生化评估。硬骨蛋白、DKK1、CTX-I 和 P1NP 的值与性别年龄匹配的健康对照组(HCs)进行了比较。我们共招募了 34 名确诊为 CRPS-1 的患者(平均年龄为 59.3 ± 10.6 岁,男性/女性各 10/24),中位病程 = 2 周(IQR 1-5);中位 VAS 评分 = 76(IQR 68-80)。足部定位的频率略高于手部定位(18/16)。CTX-I(0.3 ± 0.1 ng/ml vs 0.3 ± 0.1,P = 0.140)在CRPS-1患者和HC之间无统计学差异,而P1NP的平均血清值在CRPS-1患者中明显高于HC(70.0 ± 38.8 ng/ml vs 50.1 ± 13.6,P = 0.005)。CRPS-1 患者的硬骨蛋白和 DKK1 平均水平低于 HCs(硬骨蛋白 28.4 ± 10.8 pmol/l vs 34.1 ± 11.6,p = 0.004;DKK1 12.9 ± 10.8 pmol/l vs 24.1 ± 11.9,p = 0.001)。在骨折诱发的 CRPS-1 亚组中,所有生化评估结果均无明显统计学差异。在疾病定位、病程长短、是否存在痛觉减退、异动症、渗出运动改变以及轻度或中度/重度肿胀方面,均未发现有统计学意义的差异。硬骨素、DKK1水平、基线VAS评分或麦吉尔疼痛问卷评分之间无明显相关性。早期 CRPS-1 的骨骼受累似乎并不依赖于破骨细胞活性的增加。相反,骨形成的血清标志物却增加了。Sclerostin和DKK1的数值均有所下降,这可能表明骨细胞功能普遍丧失:论文编号:2014-001156-28。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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