Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity.

IF 8.1 1区医学 Q1 IMMUNOLOGY

Cancer immunology research Pub Date : 2024-07-02 DOI:10.1158/2326-6066.CIR-24-0395

Udo S Gaipl

引用次数: 0

Abstract

Antitumor immune responses are predominantly mediated by CD8+ cytotoxic T cells (CTLs). But immune-modulatory factors in the tumor microenvironment determine the effectiveness of these responses. In this issue, Wei and colleagues report a new role for CTL-derived IL3 in stimulating basophilic granulocytes to produce IL4, which, in turn, activates, reprograms, and stabilizes CTLs. These findings stress the importance of the crosstalk between the innate and adaptive immune systems to elicit efficient antitumor immunity. See related article by Wei et al., p. 822 (3).

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不要忘记粒细胞区在 T 细胞介导的抗肿瘤免疫中的作用。

抗肿瘤免疫反应主要由 CD8+ 细胞毒性 T 细胞（CTL）介导。但肿瘤微环境中的免疫调节因子决定了这些反应的有效性。在本期杂志中，Wei及其同事报告了CTL衍生的IL3在刺激嗜碱性粒细胞产生IL4方面的新作用，而IL4反过来又能激活、重编程和稳定CTL。这些发现强调了先天性免疫系统和适应性免疫系统之间的相互作用对激发高效抗肿瘤免疫的重要性。参见 Wei 等人的相关文章，第 822 页（3）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer immunology research ONCOLOGY-IMMUNOLOGY

CiteScore

15.60

自引率

1.00%

发文量

260

期刊介绍： Cancer Immunology Research publishes exceptional original articles showcasing significant breakthroughs across the spectrum of cancer immunology. From fundamental inquiries into host-tumor interactions to developmental therapeutics, early translational studies, and comprehensive analyses of late-stage clinical trials, the journal provides a comprehensive view of the discipline. In addition to original research, the journal features reviews and opinion pieces of broad significance, fostering cross-disciplinary collaboration within the cancer research community. Serving as a premier resource for immunology knowledge in cancer research, the journal drives deeper insights into the host-tumor relationship, potent cancer treatments, and enhanced clinical outcomes. Key areas of interest include endogenous antitumor immunity, tumor-promoting inflammation, cancer antigens, vaccines, antibodies, cellular therapy, cytokines, immune regulation, immune suppression, immunomodulatory effects of cancer treatment, emerging technologies, and insightful clinical investigations with immunological implications.