Local ozone injection compared to local glucocorticoid injection in carpal tunnel syndrome: A randomized controlled trial.

IF 1.1 4区 医学 Q3 REHABILITATION
Farnaz Hesam, Amid-Aldin Khatibi, Mohamadreza Vafaeenasab, Behnaz Tirandazi, Fereshteh Sharifi Dorcheh
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引用次数: 0

Abstract

Objectives: This study aimed to compare the effectiveness of local ozone (O3) injection versus corticosteroid injection in the treatment of mild to moderate carpal tunnel syndrome (CTS).

Patients and methods: This double-blind randomized controlled trial was performed on 42 patients (9 males, 33 females; mean age: 46.7±2.1 years; range, 18 to 70 years) with mild to moderate CTS between May 2021 and June 2021. The corticosteroid group (n=21) was injected with 40 mg triamcinolone, and in the O3 group B (n=21), 4 mL of a 10 mcg/mL oxygen (O2)-O3 mixture was injected. Symptom severity and functional impairments were assessed using a Visual Analog Scale and Boston Carpal Tunnel Questionnaire. Electrodiagnostic and ultrasonographic parameters were obtained at baseline and eight weeks after the procedure.

Results: The O2-O3 solution improved pain and Boston Carpal Tunnel Questionnaire score after eight weeks (p<0.001); however, the change was nonsignificant compared to the corticosteroid group (p>0.05). Sensory nerve and compound muscle action potential latencies were not significantly changed eight weeks after O2-O3 injection (p>0.05), while both were significantly decreased in the steroid injection group (p<0.001). Volar bulging and median nerve cross-section surface area were not improved after O2-O3 injection, while the improvement was significant in the corticosteroid arm (p=0.02).

Conclusion: Symptoms in patients with mild to moderate CTS may be alleviated by local O2-O3 injection; however, electrodiagnostic and ultrasonographic indices may be unchanged. Corticosteroid local injection may alleviate patient symptoms along with electrodiagnostic and ultrasonographic parameters.

局部臭氧注射与局部糖皮质激素注射治疗腕管综合征的比较:随机对照试验
研究目的本研究旨在比较局部臭氧(O3)注射与皮质类固醇注射治疗轻中度腕管综合征(CTS)的效果:这项双盲随机对照试验在2021年5月至2021年6月期间对42名轻中度CTS患者(9名男性,33名女性;平均年龄:46.7±2.1岁;18至70岁)进行了治疗。皮质类固醇组(21 人)注射 40 毫克曲安奈德,O3 B 组(21 人)注射 4 毫升 10 微克/毫升氧气(O2)-O3 混合物。采用视觉模拟量表和波士顿腕管问卷对症状严重程度和功能障碍进行评估。电诊断和超声波参数分别在基线和术后八周获得:结果:八周后,O2-O3 溶液改善了疼痛和波士顿腕管问卷评分(P0.05)。注射 O2-O3 八周后,感觉神经和复合肌动作电位潜伏期无明显变化(p>0.05),而类固醇注射组的感觉神经和复合肌动作电位潜伏期均明显下降(p2-O3 注射组,皮质类固醇注射组改善明显(p=0.02):结论:局部注射 O2-O3 可减轻轻度至中度 CTS 患者的症状,但电诊断和超声波检查指标可能不会改变。皮质类固醇局部注射可减轻患者症状,同时缓解电诊断和超声波检查指标。
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来源期刊
Turkish Journal of Physical Medicine and Rehabilitation
Turkish Journal of Physical Medicine and Rehabilitation Health Professions-Physical Therapy, Sports Therapy and Rehabilitation
CiteScore
2.20
自引率
0.00%
发文量
0
期刊介绍: The Turkish Journal of Physical Medicine and Rehabilitation (Formerly published as Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi) is the official journal of the Turkish Society of Physical Medicine and Rehabilitation. The journal is an international open-access, double-blind peer-reviewed periodical journal bringing the latest developments in all aspects of physical medicine and rehabilitation, and related fields. The journal publishes original articles, review articles, editorials, case reports (limited), letters to the editors. The target readership includes academic members, specialists, residents working in the fields of Physical Medicine and Rehabilitation. The language of the journal is English and it is published quarterly (in March, June, September, and December).
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