Intraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2024-06-28 DOI:10.1007/s12105-024-01664-z

Camila Oliveira Barbeiro, Heitor Albergoni Silveira, Roberto Henrique Barbeiro, Karina Helen Martins, Andreia Bufalino, Fernando Chahud, Jorge Esquiche León

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引用次数: 0

Abstract

Background: Previous studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative disorder (LPD), with histopathology reminiscent of lymphomatoid papulosis (LyP) of the skin. Microscopically, a mixed population of inflammatory cells, often including eosinophils and varying numbers of atypical lymphoid cells, frequently expressing CD30, is typical for LyP, whose clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement. To date, about 27 intraoral LyP cases have been reported. Of them, 7 cases were diagnosed as LyP type C, which is frequently confused with anaplastic large cell lymphoma (ALCL) on histopathology.

Methods: A 60-year-old male was referred for a one-month history of a tongue ulcer.

Results: Microscopy showed numerous subepithelial atypical large lymphoid cells, which expressed CD4 (with partial loss of CD3, CD5, and CD7), CD8 (few cells), CD30 (about 50%, in non-diffuse pattern with size variability), TIA-1, and Ki-67 (85%), without staining for CD56, ALK, LMP1, and EBER1/2, concerning for a diagnosis of ALCL. However, after three weeks, the lesion completely healed.

Conclusion: We present here a rare case of intraoral CD30+ T-cell LPD that we believe is the oral counterpart of cutaneous LyP type C.

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具有淋巴瘤样丘疹病 C 型特征的口腔内 CD30+ T 细胞淋巴组织增生性疾病在组织病理学和免疫组织化学上与淋巴瘤相似。

背景：以往的研究表明，至少有一种口腔内嗜酸性粒细胞溃疡最好归类为 CD30 + T 细胞淋巴组织增生性疾病（LPD），其组织病理学与皮肤淋巴瘤样丘疹病（LyP）相似。显微镜下，混合的炎症细胞群，通常包括嗜酸性粒细胞和不同数量的非典型淋巴细胞，经常表达CD30，是LyP的典型特征，其临床病理谱包括A、B、C、D、E型和DUSP22/IRF4重排的LyP。迄今为止，约有 27 例口内 LyP 病例被报道。其中7例被诊断为LyP C型，组织病理学上常与无弹性大细胞淋巴瘤（ALCL）混淆：方法：一名60岁的男性因一个月前出现舌头溃疡而被转诊：显微镜检查发现大量上皮下非典型大淋巴细胞，表达 CD4（CD3、CD5 和 CD7 部分消失）、CD8（少量细胞）、CD30（约 50%，呈非弥漫型，大小不一）、TIA-1 和 Ki-67（85%），无 CD56、ALK、LMP1 和 EBER1/2 染色，符合 ALCL 的诊断标准。然而，三周后，病灶完全愈合：我们在此介绍一例罕见的口腔内 CD30+ T 细胞 LPD 病例，我们认为它是皮肤 LyP C 型的口腔对应物。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.

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