Risk of peripheral neuropathy in patients with psoriasis and psoriatic arthritis. A prospective cohort study.

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Muscle & Nerve Pub Date : 2024-09-01 Epub Date: 2024-06-28 DOI:10.1002/mus.28196

Pietro E Doneddu, Riccardo Borroni, Angela Ceribelli, Francesca Carta, Margherita Sechi, Giulia S Moretti, Andrea Giordano, Francesco Scheveger, Federica Moret, Marco Fernandes, Francesco Gentile, Mario Valenti, Nicoletta Luciano, Elisa Bianchi, Antonio Costanzo, Pasquale E De Nittis, Carlo Selmi, Eduardo Nobile-Orazio

{"title":"Risk of peripheral neuropathy in patients with psoriasis and psoriatic arthritis. A prospective cohort study.","authors":"Pietro E Doneddu, Riccardo Borroni, Angela Ceribelli, Francesca Carta, Margherita Sechi, Giulia S Moretti, Andrea Giordano, Francesco Scheveger, Federica Moret, Marco Fernandes, Francesco Gentile, Mario Valenti, Nicoletta Luciano, Elisa Bianchi, Antonio Costanzo, Pasquale E De Nittis, Carlo Selmi, Eduardo Nobile-Orazio","doi":"10.1002/mus.28196","DOIUrl":null,"url":null,"abstract":"Introduction/aims: Laboratory and clinical data suggest a link between neurologically mediated inflammation and psoriasis, but the risk and features of peripheral neuropathy in psoriasis or psoriatic arthritis remain unknown. The aim of this exploratory study was to evaluate the risk and to describe the features of peripheral neuropathy in patients with psoriasis and psoriatic arthritis.Methods: One hundred patients with psoriasis and/or psoriatic arthritis and 100 control subjects were consecutively enrolled. Diagnostic confirmation included electrophysiological examination, skin biopsy, and nerve ultrasound for confirmed polyneuropathy.Results: Nine patients were diagnosed with confirmed polyneuropathy, while none of the control subjects had the condition (relative risk [RR] = 19.00, 95% confidence interval [CI] = 1.12-322.11). Specific relative risks for polyneuropathy were 22.09 (95% CI = 1.17-416.43) in psoriasis patients and 18.75 (95% CI = 1.07-327.62) in psoriatic arthritis patients. The observed polyneuropathy in all nine patients was length-dependent, symmetrical, and predominantly sensory, with minimal or no disability. Comorbidities and exposure to therapies known to increase the risk of polyneuropathy were more frequent in psoriasis and/or psoriatic arthritis patients compared to controls (42% vs. 4%, p = .0001). Analyzing data after excluding possible contributory causes, the risk of polyneuropathy in patients with psoriasis and/or psoriatic arthritis was not significant.Discussion: Psoriasis and psoriatic arthritis appear to be associated with an increased risk of polyneuropathy. This increased risk seems to be linked to the higher prevalence of contributing factors for polyneuropathy, rather than a direct increase in neuropathy risk specifically related to psoriasis and psoriatic arthritis.","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Muscle & Nerve","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mus.28196","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction/aims: Laboratory and clinical data suggest a link between neurologically mediated inflammation and psoriasis, but the risk and features of peripheral neuropathy in psoriasis or psoriatic arthritis remain unknown. The aim of this exploratory study was to evaluate the risk and to describe the features of peripheral neuropathy in patients with psoriasis and psoriatic arthritis.

Methods: One hundred patients with psoriasis and/or psoriatic arthritis and 100 control subjects were consecutively enrolled. Diagnostic confirmation included electrophysiological examination, skin biopsy, and nerve ultrasound for confirmed polyneuropathy.

Results: Nine patients were diagnosed with confirmed polyneuropathy, while none of the control subjects had the condition (relative risk [RR] = 19.00, 95% confidence interval [CI] = 1.12-322.11). Specific relative risks for polyneuropathy were 22.09 (95% CI = 1.17-416.43) in psoriasis patients and 18.75 (95% CI = 1.07-327.62) in psoriatic arthritis patients. The observed polyneuropathy in all nine patients was length-dependent, symmetrical, and predominantly sensory, with minimal or no disability. Comorbidities and exposure to therapies known to increase the risk of polyneuropathy were more frequent in psoriasis and/or psoriatic arthritis patients compared to controls (42% vs. 4%, p = .0001). Analyzing data after excluding possible contributory causes, the risk of polyneuropathy in patients with psoriasis and/or psoriatic arthritis was not significant.

Discussion: Psoriasis and psoriatic arthritis appear to be associated with an increased risk of polyneuropathy. This increased risk seems to be linked to the higher prevalence of contributing factors for polyneuropathy, rather than a direct increase in neuropathy risk specifically related to psoriasis and psoriatic arthritis.

查看原文本刊更多论文

银屑病和银屑病关节炎患者发生周围神经病变的风险。前瞻性队列研究。

导言/目的：实验室和临床数据表明，神经介导的炎症与银屑病之间存在联系，但银屑病或银屑病关节炎周围神经病变的风险和特征仍然未知。这项探索性研究旨在评估银屑病和银屑病关节炎患者发生周围神经病变的风险并描述其特征：100 名银屑病和/或银屑病关节炎患者以及 100 名对照组受试者被连续纳入研究。诊断确认包括电生理检查、皮肤活检和神经超声检查，以确诊多发性神经病：结果：9 名患者被确诊为多发性神经病，而对照组中没有一人患病（相对风险 [RR] = 19.00，95% 置信区间 [CI] = 1.12-322.11）。银屑病患者多发性神经病的特定相对风险为 22.09（95% CI = 1.17-416.43），银屑病关节炎患者为 18.75（95% CI = 1.07-327.62）。在所有九名患者中观察到的多发性神经病均为长度依赖性、对称性、以感觉为主，残疾程度极低或没有残疾。与对照组相比，银屑病和/或银屑病关节炎患者合并症和接触已知会增加多发性神经病风险的疗法的比例更高（42% 对 4%，P = .0001）。在排除可能的诱因后分析数据，银屑病和/或银屑病关节炎患者发生多发性神经病的风险并不显著：讨论：银屑病和银屑病关节炎似乎与多发性神经病的风险增加有关。讨论：银屑病和银屑病关节炎似乎与多发性神经病的风险增加有关，这种风险增加似乎与多发性神经病的诱发因素较多有关，而不是与银屑病和银屑病关节炎直接相关的神经病风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Muscle & Nerve 医学-临床神经学

CiteScore

6.40

自引率

5.90%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.

文献相关原料

公司名称	产品信息	采购帮参考价格