Extraocular muscle volume on time-of-flight magnetic resonance angiography in patients with myasthenia gravis.

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Muscle & Nerve Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI:10.1002/mus.28192

Pei Chen, Qin Zhou, Xiaoxiao Zhao, Yingqian Chen, Zhongqiang Lin, Mengzhu Wang, Zhiyun Yang, Weibin Liu

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Abstract

Introduction/aims: Despite being a prominent feature of myasthenia gravis (MG), extraocular muscle (EOM) has received little attention in clinical research. The aim of this study was to examine EOM volume in patients with MG and controls using time-of-flight magnetic resonance angiography (TOF-MRA).

Methods: EOM volumes (overall and individual rectus muscles) were calculated using TOF-MRA images and compared between MG patients (including subgroups) and controls. The correlation between EOM volume and disease duration was examined. Predictive equations for the selected parameters were developed using multiple linear regression analysis.

Results: EOM volume was lower in MG patients than controls, especially in MG patients with ophthalmoparesis (MG-O). MG-O exhibited a moderate negative correlation between EOM volume and disease duration. Multiple linear regression showed that disease duration and EOM status (ophthalmoparesis or not) account for 48.4% of EOM volume.

Discussion: Patients with MG show atrophy of the EOMs, especially those with ophthalmoparesis and long disease duration.

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飞行时间磁共振血管造影显示重症肌无力患者的眼外肌体积。

导言/目的：尽管眼外肌（EOM）是重症肌无力（MG）的一个显著特征，但在临床研究中却很少受到关注。本研究旨在利用飞行时间磁共振血管造影术（TOF-MRA）检查 MG 患者和对照组的眼外肌体积：方法：使用TOF-MRA图像计算EOM体积（整体和单个直肌），并在MG患者（包括亚组）和对照组之间进行比较。研究了EOM体积与病程的相关性。采用多元线性回归分析为所选参数建立了预测方程：结果：MG 患者的 EOM 体积低于对照组，尤其是伴有眼肌麻痹的 MG 患者（MG-O）。MG-O患者的EOM体积与病程呈中度负相关。多元线性回归显示，病程和EOM状态（是否眼瘫）占EOM体积的48.4%：讨论：MG患者的EOM会出现萎缩，尤其是那些患有眼瘫且病程较长的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Muscle & Nerve 医学-临床神经学

CiteScore

6.40

自引率

5.90%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.

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