Small molecule-regulated switches to provide functional control of CAR T cells within the patient.

IF 3.6 3区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Expert Opinion on Biological Therapy Pub Date : 2024-06-01 Epub Date: 2024-06-29 DOI:10.1080/14712598.2024.2371034

Charlotte U Zajc, Elise Sylvander, Manfred Lehner, Michael W Traxlmayr

引用次数: 0

Abstract

Introduction: CAR T cells have generated great excitement due to their remarkable clinical response rates in selected hematologic malignancies. However, these engineered immune cells are living drugs which are hard to control after administration.

Areas covered: We discuss small molecule-regulated switch systems which can potentially be used to control CAR T cell function within the patient, as well as the most important obstacles in the CAR T cell field, which might be overcome with those switch systems.

Expert opinion: There is an urgent need to develop advanced switch systems. Once available, we expect that they will open up new avenues for future CAR T cell generations.

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通过小分子调控开关，对患者体内的 CAR T 细胞进行功能控制。

导言：CAR T 细胞对某些血液系统恶性肿瘤的临床反应率非常显著，因此引起了极大的关注。然而，这些工程免疫细胞是活体药物，用药后很难控制：我们讨论了有可能用于控制患者体内 CAR T 细胞功能的小分子调控开关系统，以及 CAR T 细胞领域最重要的障碍，这些障碍可能通过这些开关系统得以克服：我们迫切需要开发先进的切换系统。一旦问世，我们预计它们将为未来的 CAR T 细胞世代开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Biological Therapy 医学-生物工程与应用微生物

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.