NUAK: never underestimate a kinase.

IF 5.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Essays in biochemistry Pub Date : 2024-11-18 DOI:10.1042/EBC20240005

George L Skalka, Declan Whyte, Dominika Lubawska, Daniel J Murphy

引用次数: 0

Abstract

NUAK1 and NUAK2 belong to a family of kinases related to the catalytic α-subunits of the AMP-activated protein kinase (AMPK) complexes. Despite canonical activation by the tumour suppressor kinase LKB1, both NUAKs exhibit a spectrum of activities that favour tumour development and progression. Here, we review similarities in structure and function of the NUAKs, their regulation at gene, transcript and protein level, and discuss their phosphorylation of specific downstream targets in the context of the signal transduction pathways and biological activities regulated by each or both NUAKs.

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NUAK：永远不要低估激酶。

NUAK1和NUAK2属于激酶家族，与AMP激活蛋白激酶（AMPK）复合物的催化α亚基有关。尽管NUAKs是由肿瘤抑制激酶LKB1激活的，但它们都表现出一系列有利于肿瘤发生和发展的活性。在此，我们回顾了 NUAKs 在结构和功能上的相似性，它们在基因、转录本和蛋白质水平上的调控，并结合信号转导途径和受每种或两种 NUAKs 调控的生物活性，讨论了它们对特定下游靶点的磷酸化作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Essays in biochemistry 生物-生化与分子生物学

CiteScore

10.50

自引率

0.00%

发文量

105

审稿时长

>12 weeks

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