Observable Atrial and Ventricular Fibrillation Episode Durations Are Conformant With a Power Law Based on System Size and Spatial Synchronization.

IF 9.1 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation. Arrhythmia and electrophysiology Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI:10.1161/CIRCEP.123.012684

Dhani Dharmaprani, Kathryn Tiver, Sobhan Salari Shahrbabaki, Evan V Jenkins, Darius Chapman, Campbell Strong, Jing X Quah, Ivaylo Tonchev, Luke O'Loughlin, Lewis Mitchell, Matthew Tung, Waheed Ahmad, Nik Stoyanov, Martin Aguilar, Steven A Niederer, Caroline H Roney, Martyn P Nash, Richard H Clayton, Stanley Nattel, Anand N Ganesan

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引用次数: 0

Abstract

Background: Atrial fibrillation (AF) and ventricular fibrillation (VF) episodes exhibit varying durations, with some spontaneously ending quickly while others persist. A quantitative framework to explain episode durations remains elusive. We hypothesized that observable self-terminating AF and VF episode lengths, whereby durations are known, would conform with a power law based on the ratio of system size and correlation length ([Formula: see text].

Methods: Using data from computer simulations (2-dimensional sheet and 3-dimensional left-atrial), human ischemic VF recordings (256-electrode sock, n=12 patients), and human AF recordings (64-electrode basket-catheter, n=9 patients; 16-electrode high definition-grid catheter, n=42 patients), conformance with a power law was assessed using the Akaike information criterion, Bayesian information criterion, coefficient of determination (R², significance=P<0.05) and maximum likelihood estimation. We analyzed fibrillatory episode durations and [Formula: see text], computed by taking the ratio between system size ([Formula: see text], chamber/simulation size) and correlation length (xi, estimated from pairwise correlation coefficients over electrode/node distance).

Results: In all computer models, the relationship between episode durations and [Formula: see text] was conformant with a power law (Aliev-Panfilov R²: 0.90, P<0.001; Courtemanche R²: 0.91, P<0.001; Luo-Rudy R²: 0.61, P<0.001). Observable clinical AF/VF durations were also conformant with a power law relationship (VF R²: 0.86, P<0.001; AF basket R²: 0.91, P<0.001; AF grid R²: 0.92, P<0.001). [Formula: see text] also differentiated between self-terminating and sustained episodes of AF and VF (P<0.001; all systems), as well as paroxysmal versus persistent AF (P<0.001). In comparison, other electrogram metrics showed no statistically significant differences (dominant frequency, Shannon Entropy, mean voltage, peak-peak voltage; P>0.05).

Conclusions: Observable fibrillation episode durations are conformant with a power law based on system size and correlation length.

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可观察到的心房颤动和室颤发作持续时间符合基于系统规模和空间同步性的幂律。

背景：心房颤动（AF）和心室颤动（VF）发作的持续时间各不相同，有些会很快自发结束，而有些则会持续存在。目前仍未找到解释发作持续时间的定量框架。我们假设，在已知持续时间的情况下，可观察到的自发终止房颤和室颤发作长度将符合基于系统大小和相关长度比值的幂律（[公式：见正文]）：方法：利用计算机模拟（二维片状和三维左心房）、人体缺血性室颤记录（256 个电极的袜子，12 名患者）和人体房颤记录（64 个电极的篮式导管，9 名患者；16 个电极的高清栅格导管，42 名患者）中的数据，使用阿凯克信息准则、贝叶斯信息准则、决定系数（R2，显著性=PResults）评估与幂律的一致性：在所有计算机模型中，发作持续时间与[公式：见正文]之间的关系符合幂律（阿利耶夫-潘菲洛夫 R2：0.90，P2：0.91，P2：0.61，P2：0.86，P2：0.91，P2：0.92，PPPP>0.05）：结论：可观察到的心颤发作持续时间符合基于系统规模和相关长度的幂律。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation. Arrhythmia and electrophysiology 医学-心血管系统

CiteScore

13.70

自引率

4.80%

发文量

187

审稿时长

4-8 weeks

期刊介绍： Circulation: Arrhythmia and Electrophysiology is a journal dedicated to the study and application of clinical cardiac electrophysiology. It covers a wide range of topics including the diagnosis and treatment of cardiac arrhythmias, as well as research in this field. The journal accepts various types of studies, including observational research, clinical trials, epidemiological studies, and advancements in translational research.