Single-nucleus transcriptomics reveals adrenergic and STAT3 signalling in paradoxical low-flow low-gradient-specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment.

IF 10.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Research Pub Date : 2024-11-05 DOI:10.1093/cvr/cvae137

Xingbo Xu, Xiaoying Tan, Baolong Cui, Niels B Paul, Manar Elkenani, Bo E Beuthner, Weichao Li, Belal A Mohamed, Moritz Schnelle, Miriam Puls, Elisabeth M Zeisberg, Michael Zeisberg, Tim Beißbarth, Karl Toischer, Gerd Hasenfuß

引用次数: 0

查看原文本刊更多论文

单核转录组学揭示了矛盾的低流量低梯度特异性心肌细胞亚群中的肾上腺素能和 STAT3 信号：对主动脉瓣狭窄发病机制和治疗的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cardiovascular Research 医学-心血管系统

CiteScore

21.50

自引率

3.70%

发文量

547

审稿时长

1 months

期刊介绍： Cardiovascular Research Journal Overview: International journal of the European Society of Cardiology Focuses on basic and translational research in cardiology and cardiovascular biology Aims to enhance insight into cardiovascular disease mechanisms and innovation prospects Submission Criteria: Welcomes papers covering molecular, sub-cellular, cellular, organ, and organism levels Accepts clinical proof-of-concept and translational studies Manuscripts expected to provide significant contribution to cardiovascular biology and diseases