[Effect of metabolic reprogramming on abdominal aortic aneurysm].

Q3 Medicine
生理学报 Pub Date : 2024-06-25
Ge Wang, Mei-Li Wang
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引用次数: 0

Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening disease that remains undetected until it acutely ruptures. Due to lack of effective pharmaceutic therapies, it is urgent to explore new prevention and treatment strategies. Metabolic reprogramming is a cellular process through which cells change their metabolic patterns to meet material and energy requirements, including glucose metabolism, lipid metabolism and amino acid metabolism. Recently, the regulatory role of metabolic reprogramming in cardiovascular diseases, especially AAA, has attracted significant attention. This review article focuses on the research progress regarding the effects of metabolic reprogramming of vascular smooth muscle cells (VSMCs) and macrophages on the occurrence and development of AAA, especially their roles in major pathological processes such as VSMCs apoptosis and phenotype transformation, extracellular matrix remodeling, oxidative stress, and inflammatory response. The aim is to provide new clues for the mechanism research and clinical treatment of AAA from the perspective of metabolism.

[代谢重编程对腹主动脉瘤的影响]。
腹主动脉瘤(AAA)是一种危及生命的疾病,在急性破裂前一直未被发现。由于缺乏有效的药物疗法,探索新的预防和治疗策略迫在眉睫。代谢重编程是细胞改变其代谢模式以满足物质和能量需求的过程,包括葡萄糖代谢、脂质代谢和氨基酸代谢。最近,代谢重编程在心血管疾病(尤其是 AAA)中的调控作用引起了广泛关注。这篇综述文章重点探讨了血管平滑肌细胞(VSMC)和巨噬细胞代谢重编程对 AAA 发生和发展的影响,尤其是它们在血管平滑肌细胞凋亡和表型转化、细胞外基质重塑、氧化应激和炎症反应等主要病理过程中的作用。目的是从新陈代谢的角度为 AAA 的机制研究和临床治疗提供新的线索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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