Alanna J Church, Claire E Wakefield, Kate Hetherington, Jack F Shern
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引用次数: 0
Abstract
The completion of multiple national pediatric precision oncology platform trials and the incorporation of standardized molecular profiling into the diagnostic care of pediatric and young adult patients with sarcomas have proven the feasibility and potential of the approach. In this work, we explore the current state of the art of precision oncology for pediatric and young adults with sarcoma. We highlight important lessons learned and the challenges that should be addressed in the next generation of trials. The chapter outlines current efforts to improve standardization of molecular assays, harmonization of data collection, and novel molecular tools such as cell-free DNA analyses. Finally, we discuss the impacts and psychosocial outcomes experienced by patients and communication strategies for providers.
多项国家级儿科精准肿瘤学平台试验的完成，以及将标准化分子谱分析纳入儿科和年轻成人肉瘤患者的诊断治疗，证明了这一方法的可行性和潜力。在这项研究中，我们探讨了精准肿瘤学在儿科和年轻成人肉瘤患者中的应用现状。我们强调了重要的经验教训以及下一代试验中应解决的挑战。本章概述了目前为提高分子检测标准化、统一数据收集和新型分子工具（如无细胞 DNA 分析）所做的努力。最后，我们讨论了患者所经历的影响和社会心理结果，以及医疗服务提供者的沟通策略。
期刊介绍：
The Ed Book is a National Library of Medicine–indexed collection of articles written by ASCO Annual Meeting faculty and invited leaders in oncology. Ed Book was launched in 1985 to highlight standards of care and inspire future therapeutic possibilities in oncology. Published annually, each volume highlights the most compelling research and developments across the multidisciplinary fields of oncology and serves as an enduring scholarly resource for all members of the cancer care team long after the Meeting concludes. These articles address issues in the following areas, among others: Immuno-oncology, Surgical, radiation, and medical oncology, Clinical informatics and quality of care, Global health, Survivorship.
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