Divergent pentafluoroethylation of styrene derivatives using CuCF2CF3†

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-06-25 DOI:10.1039/D4QO00768A

Zhengjie Fu and Gavin Chit Tsui

引用次数: 0

Abstract

A series of pentafluoroethylation reactions of styrene derivatives are described using the [CuCF₂CF₃] reagent prepared from low-cost pentafluoroethane (HCF₂CF₃). Under aerobic conditions, chloropentafluoroethylation, dimerization-pentafluoroethylation, vinylic pentafluoroethylation, formyloxylation-pentafluoroethylation and hydroxypentafluoroethylation can be achieved using styrenes to generate various functionalized products containing the CF₂CF₃ group. It is remarkable that a single reagent is capable of such divergent reactivities with readily available feedstocks.

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使用 CuCF2CF3 对苯乙烯衍生物进行歧化五氟乙烷化反应

利用从低成本五氟乙烷（HCF2CF3）制备的[CuCF2CF3]试剂，描述了苯乙烯衍生物的一系列五氟乙基化反应。在有氧条件下，利用苯乙烯可以实现氯五氟乙基化、二聚化-五氟乙基化、乙烯基五氟乙基化、甲酰氧基化-五氟乙基化和羟基五氟乙基化，生成含有 CF2CF3 基团的各种官能化产物。令人瞩目的是，一种试剂就能利用现成的原料产生如此不同的反应活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.