Gold-Catalyzed C–N Cross-Coupling Reactions of Aryl Iodides with Alkyl Nitriles or Silver Cyanate

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-06-24 DOI:10.1021/acs.orglett.4c01538

Hongyan Liu, and , Bo Xu*,

引用次数: 0

Abstract

We have gold-catalyzed C–N cross-couplings of aryl iodides with aliphatic nitriles. Although nitriles are usually challenging nitrogen cross-coupling partners, they could be activated by base-mediated deprotonation and isomerization. The method utilizes widely available substrates in moderate to good yields to provide various N-aryl compounds. In addition, a similar strategy could be extended to the cross-couplings of aryl iodides with silver cyanate. The protocol features high humidity/air tolerance and works inter- and intramolecularly.

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金催化的芳基碘化物与烷基腈或氰酸银的 C-N 交叉偶联反应。

我们用金催化了芳基碘化物与脂肪族腈的 C-N 交叉偶联反应。虽然腈类通常是具有挑战性的氮交叉偶联伙伴，但它们可以通过碱介导的去质子化和异构化被激活。该方法利用广泛可用的底物，以中等至良好的产率提供各种 N-芳基化合物。此外，类似的策略还可扩展到芳基碘化物与氰酸银的交叉耦合。该方法对湿度/空气的耐受性高，可在分子间和分子内进行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.