Tripartite interactions between viruses, parasites, and mosquitoes

IF 5.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2024-06-20 DOI:10.1016/j.cois.2024.101222

Michelle Schinkel, Teun Bousema, Ronald P van Rij

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引用次数: 0

Abstract

Mosquito-borne diseases have a major impact on global human health. Biological agents that colonize the mosquito vector are increasingly explored as an intervention strategy to prevent vector-borne disease transmission. For instance, the release of mosquitoes carrying the endosymbiotic bacterium Wolbachia effectively reduced dengue virus incidence and disease. Insect-specific viruses are likewise considered as biocontrol agents against vector-borne diseases. While most studies focused on insect-specific viruses as an intervention against arthropod-borne viruses, we here consider whether mosquito-specific viruses may affect the transmission of the malaria-causing Plasmodium parasite by Anopheles mosquitoes. Although there is no direct experimental evidence addressing this question, we found that viral infections in dipteran insects activate some of the immune pathways that are antiparasitic in Anopheles. These findings suggest that indirect virus–parasite interactions could occur and that insect-specific viruses may modulate malaria transmission. Tripartite interactions between viruses, parasites, and Anopheles mosquitoes thus merit further investigation.

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病毒、寄生虫和蚊子之间的三方互动。

蚊媒疾病对全球人类健康有着重大影响。人们越来越多地探索将蚊媒定植的生物制剂作为预防病媒传播疾病的干预策略。例如，释放携带内共生细菌 Wolbachia 的蚊子可有效减少登革热病毒的发病率和疾病。昆虫特异性病毒同样被认为是防止病媒传播疾病的生物控制剂。虽然大多数研究都集中于昆虫特异性病毒作为对节肢动物传播病毒的干预，但我们在此考虑蚊子特异性病毒是否会影响疟蚊传播导致疟疾的疟原虫。虽然没有直接的实验证据来解决这个问题，但我们发现，双翅目昆虫的病毒感染会激活按蚊的一些抗寄生虫免疫途径。这些发现表明，病毒与寄生虫之间可能会发生间接的相互作用，昆虫特异性病毒可能会调节疟疾的传播。因此，病毒、寄生虫和按蚊之间的三方相互作用值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.