Incident stroke in individuals with peripartum cardiomyopathy

IF 3.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal Pub Date : 2024-06-21 DOI:10.1016/j.ahj.2024.06.006

Chinwe Ibeh MD , Erin R. Kulick PhD, MPH , Amelia K. Boehme PhD , Alexander M. Friedman MD , Eliza C. Miller MD, MS , Natalie A. Bello MD, MPH

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引用次数: 0

Abstract

Background

Peripartum cardiomyopathy (PPCM), a form of heart failure with reduced ejection fraction (HFrEF) that occurs during the final month of pregnancy through the first 5 months postpartum, is associated with heightened risk for maternal morbidity and mortality. Stroke is a common complication of HFrEF but there is limited data on the incidence of stroke in PPCM.

Methods

Using statewide, nonfederal administrative data from 2000 to 2015, we analyzed age-adjusted risk of stroke within 3 years after PPCM-associated pregnancies.

Results

PPCM was associated with a greater than 4-fold increased risk of pregnancy-related stroke (aHR 4.7, 95% CI: 3.0-7.5). This risk was highest at the time of PPCM diagnosis but remained elevated in the first postpartum year.

Conclusion

Our findings confirm the strong association between PPCM and stroke, with risk that persists throughout and after the peripartum period.

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围产期心肌病患者的中风发病率。

背景：围产期心肌病（PPCM）是一种射血分数降低的心力衰竭（HFrEF），发生在妊娠的最后一个月至产后的前 5 个月，与孕产妇发病率和死亡率的增加有关。中风是 HFrEF 常见的并发症，但有关 PPCM 中风发生率的数据却很有限：利用 2000-2015 年全州非联邦行政数据，我们分析了与 PPCM 相关的妊娠后 3 年内经年龄调整的中风风险：结果：PPCM 与妊娠相关中风的风险增加了四倍多（aHR 4.7，95% CI：3.0-7.5）。这一风险在确诊 PPCM 时最高，但在产后第一年仍然较高：我们的研究结果证实了 PPCM 与中风之间的密切联系，其风险在整个围产期及之后持续存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.