Identification of prognostic biomarkers for cholangiocarcinoma by combined analysis of molecular characteristics of clinical MVI subtypes and molecular subtypes
IF 4.3 3区 材料科学Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Ming-Yue Li , Ya-Hui Liu , Feng Wei , Ping Zhang , Xiao-Dong Sun , Meng Wang , Xiao-Hong Du , Jun-Feng Ye , Wei Qiu , Xiao-Ju Shi , Bai Ji , Ying-Chao Wang , Chao Jiang , Wen-Gang Chai , Bo Huang , Xing-Kai Liu , Qing-Min Chen , Yu Fu , Xin-Tong Hu , Li-Guo Chen , Guo-Yue Lv
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引用次数: 0
Abstract
Cholangiocarcinoma (CCA) is widely noted for its high degree of malignancy, rapid progression, and limited therapeutic options. This study was carried out on transcriptome data of 417 CCA samples from different anatomical locations. The effects of lipid metabolism related genes and immune related genes as CCA classifiers were compared. Key genes were derived from MVI subtypes and better molecular subtypes. Pathways such as epithelial mesenchymal transition (EMT) and cell cycle were significantly activated in MVI-positive group. CCA patients were classified into three (four) subtypes based on lipid metabolism (immune) related genes, with better prognosis observed in lipid metabolism-C1, immune-C2, and immune-C4. IPTW analysis found that the prognosis of lipid metabolism-C1 was significantly better than that of lipid metabolism-C2 + C3 before and after correction. KRT16 was finally selected as the key gene. And knockdown of KRT16 inhibited proliferation, migration and invasion of CCA cells.
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