The Discovery of Extracellular Vesicles and Their Emergence as a Next-Generation Therapy.

IF 16.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation research Pub Date : 2024-06-21 Epub Date: 2024-06-20 DOI:10.1161/CIRCRESAHA.123.323054

Alin Rai, Bethany Claridge, Jonathan Lozano, David W Greening

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引用次数: 0

Abstract

From their humble discovery as cellular debris to cementing their natural capacity to transfer functional molecules between cells, the long-winded journey of extracellular vesicles (EVs) now stands at the precipice as a next-generation cell-free therapeutic tool to revolutionize modern-day medicine. This perspective provides a snapshot of the discovery of EVs to their emergence as a vibrant field of biology and the renaissance they usher in the field of biomedical sciences as therapeutic agents for cardiovascular pathologies. Rapid development of bioengineered EVs is providing innovative opportunities to overcome biological challenges of natural EVs such as potency, cargo loading and enhanced secretion, targeting and circulation half-life, localized and sustained delivery strategies, approaches to enhance systemic circulation, uptake and lysosomal escape, and logistical hurdles encompassing scalability, cost, and time. A multidisciplinary collaboration beyond the field of biology now extends to chemistry, physics, biomaterials, and nanotechnology, allowing rapid development of designer therapeutic EVs that are now entering late-stage human clinical trials.

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细胞外囊泡的发现及其作为新一代疗法的出现。

细胞外囊泡（EVs）从最初作为细胞碎片被发现，到其在细胞间转移功能分子的天然能力得到巩固，其漫长的发展历程如今已成为下一代无细胞治疗工具，有望彻底改变现代医学。本视角简要介绍了从发现细胞外囊泡到其成为一个充满活力的生物学领域，以及其作为心血管疾病治疗剂在生物医学领域所带来的复兴。生物工程 EVs 的快速发展为克服天然 EVs 面临的生物学挑战提供了创新机会，这些挑战包括效力、货物装载和增强分泌、靶向性和循环半衰期、局部和持续递送策略、增强全身循环的方法、吸收和溶酶体逃逸，以及包括可扩展性、成本和时间在内的后勤障碍。现在，多学科合作已超越生物学领域，扩展到化学、物理学、生物材料和纳米技术领域，使设计治疗型 EVs 的快速开发成为可能，这些 EVs 现已进入后期人体临床试验阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation research 医学-外周血管病

CiteScore

29.60

自引率

2.00%

发文量

535

审稿时长

3-6 weeks

期刊介绍： Circulation Research is a peer-reviewed journal that serves as a forum for the highest quality research in basic cardiovascular biology. The journal publishes studies that utilize state-of-the-art approaches to investigate mechanisms of human disease, as well as translational and clinical research that provide fundamental insights into the basis of disease and the mechanism of therapies. Circulation Research has a broad audience that includes clinical and academic cardiologists, basic cardiovascular scientists, physiologists, cellular and molecular biologists, and cardiovascular pharmacologists. The journal aims to advance the understanding of cardiovascular biology and disease by disseminating cutting-edge research to these diverse communities. In terms of indexing, Circulation Research is included in several prominent scientific databases, including BIOSIS, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, and MEDLINE. This ensures that the journal's articles are easily discoverable and accessible to researchers in the field. Overall, Circulation Research is a reputable publication that attracts high-quality research and provides a platform for the dissemination of important findings in basic cardiovascular biology and its translational and clinical applications.