Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Georgina Nakafero, Matthew J Grainge, Tim Card, Christian D Mallen, Jonathan S Nguyen Van-Tam, Abhishek Abhishek
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引用次数: 0

Abstract

Objective: To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality.

Design: Data for adults with IBD diagnosed before the 1 September 2018 were extracted from the Clinical Practice Research Datalink Gold. We calculated the proportion of people vaccinated against seasonal influenza in the 2018-2019 influenza cycle. To investigate vaccine effectiveness, we calculated the propensity score (PS) for vaccination and conducted Cox proportional hazard regression with inverse-probability treatment weighting on PS. We employed self-controlled case series analysis to investigate the association between vaccination and IBD flare.

Results: Data for 13 631 people with IBD (50.4% male, mean age 52.9 years) were included. Fifty percent were vaccinated during the influenza cycle, while 32.1% were vaccinated on time, that is, before the seasonal influenza virus circulated in the community. IIV was associated with reduced all-cause mortality (aHR (95% CI): 0.73 (0.55,0.97) but not hospitalisation for pneumonia (aHR (95% CI) 0.52 (0.20-1.37), including in the influenza active period (aHR (95% CI) 0.48 (0.18-1.27)). Administration of the IIV was not associated with IBD flare.

Conclusion: The uptake of influenza vaccine was low in people with IBD, and the majority were not vaccinated before influenza virus circulated in the community. Vaccination with the IIV was not associated with IBD flare. These findings add to the evidence to promote vaccination against influenza in people with IBD.

炎症性肠病患者对灭活型流感疫苗的接种率、安全性和有效性:英国范围内的一项研究。
目的调查:(1) 英国范围内炎症性肠病(IBD)成人的灭活流感疫苗(IIV)接种率;(2) 流感疫苗接种与 IBD 爆发之间的关联;(3) IIV 在预防发病率和死亡率方面的有效性:我们从临床实践研究数据链接金沙国际娱乐网址(Clinical Practice Research Datalink Gold)中提取了2018年9月1日前确诊的IBD成人患者数据。我们计算了2018-2019年流感周期中接种季节性流感疫苗的人数比例。为了研究疫苗的有效性,我们计算了疫苗接种的倾向得分(PS),并对PS进行了逆概率治疗加权的Cox比例危险回归。我们采用了自控病例系列分析来研究疫苗接种与 IBD 复发之间的关联:纳入了 13 631 名 IBD 患者(50.4% 为男性,平均年龄 52.9 岁)的数据。50%的患者在流感周期内接种了疫苗,32.1%的患者在季节性流感病毒在社区流行之前及时接种了疫苗。IIV 可降低全因死亡率(aHR (95% CI):0.73 (0.55,0.97)),但不能降低肺炎住院率(aHR (95% CI) 0.52 (0.20-1.37)),包括在流感活跃期(aHR (95% CI) 0.48 (0.18-1.27))。接种 IIV 与 IBD 爆发无关:结论:IBD 患者对流感疫苗的接种率很低,而且大多数人在流感病毒在社区流行之前没有接种疫苗。接种 IIV 与 IBD 爆发无关。这些发现为促进IBD患者接种流感疫苗提供了更多证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMJ Open Gastroenterology
BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.90
自引率
3.20%
发文量
68
审稿时长
2 weeks
期刊介绍: BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.
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