Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone

IF 2.9 3区医学 Q2 DERMATOLOGY

Journal of Dermatology Pub Date : 2024-06-19 DOI:10.1111/1346-8138.17333

Salin Kiratikanon, Ananya Maneenut, Nopadon Noppakun, Chanat Kumtornrut

{"title":"Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone","authors":"Salin Kiratikanon, Ananya Maneenut, Nopadon Noppakun, Chanat Kumtornrut","doi":"10.1111/1346-8138.17333","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.</p>\n </section>\n \n <section>\n \n <h3> Objective<b>s</b></h3>\n \n <p>The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Twenty-five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], −59.74 to 74.94); TEWL, −2.36 (95% CI, −5.77 to 1.06); L* value, 0.51 (95% CI, −0.70 to 1.72); individual typology angle, 1.65 (95% CI −2.27 to 5.57); pH, 0.01 (95% CI −0.43 to 0.46); pore size, −0.24 (95% CI, −1.21 to 0.73); and SSL levels, 7.60 (95% CI −59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (−0.076 [95% CI, −0.141 to −0.010] and −0.016 [95% CI, −0.033 to −0.001]). R3 and R4 (representing tiring effects) were also improved (−0.091 [95% CI, −0.158 to −0.025] and −0.022 [95% CI, −0.044 to −0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.</p>\n </section>\n </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 11","pages":"1454-1460"},"PeriodicalIF":2.9000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.17333","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated.

Objectives

The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size.

Materials and Methods

Twenty-five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline.

Results

Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], −59.74 to 74.94); TEWL, −2.36 (95% CI, −5.77 to 1.06); L* value, 0.51 (95% CI, −0.70 to 1.72); individual typology angle, 1.65 (95% CI −2.27 to 5.57); pH, 0.01 (95% CI −0.43 to 0.46); pore size, −0.24 (95% CI, −1.21 to 0.73); and SSL levels, 7.60 (95% CI −59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (−0.076 [95% CI, −0.141 to −0.010] and −0.016 [95% CI, −0.033 to −0.001]). R3 and R4 (representing tiring effects) were also improved (−0.091 [95% CI, −0.158 to −0.025] and −0.022 [95% CI, −0.044 to −0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months.

Conclusion

Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.

查看原文本刊更多论文

螺内酯对口服螺内酯治疗痤疮妇女皮肤生物物理特性的影响。

背景：螺内酯（SPL）是治疗女性痤疮的一种有效方法，但它对皮肤生物物理特性的其他影响仍有待研究：本研究旨在探讨口服螺内酯治疗女性痤疮对皮肤生物物理特性的影响，包括水合作用、经表皮失水（TEWL）、皮肤表面脂质（SSL）水平、机械特性、颜色、pH值和毛孔大小：对 25 名接受口服 SPL 治疗的泰国女性痤疮患者进行了为期 6 个月的随访。在基线和口服 SPL 治疗 2、4 和 6 个月后，对前额、胸部和手臂内侧的皮肤水合作用、TEWL、SSL 水平、机械性能、颜色、pH 值和毛孔大小进行了评估。此外，还对面部和上背部的毛孔大小进行了评估。临床结果为每次检查时这些皮肤生物物理特性与基线相比的变化：结果：在整个研究过程中，皮肤水合作用、TEWL、SSL 水平、颜色、pH 值和毛孔大小均保持稳定。6 个月后，面部皮肤参数发生了以下变化：水合水平，7.60（95% 置信区间 [CI]，-59.74 至 74.94）；TEWL，-2.36（95% 置信区间，-5.77 至 1.06）；L* 值，0.51（95% CI，-0.70 至 1.72）；个体类型学角度，1.65（95% CI -2.27 至 5.57）；pH 值，0.01（95% CI -0.43 至 0.46）；毛孔大小，-0.24（95% CI，-1.21 至 0.73）；以及 SSL 水平，7.60（95% CI -59.74 至 74.94）。面部机械性能得到改善。R0（表示皮肤紧致度）和 R1（表示弹性）显著下降（-0.076 [95% CI, -0.141 to -0.010]和-0.016 [95% CI, -0.033 to -0.001]）。R3 和 R4（代表疲劳效应）也有所改善（-0.091 [95% CI, -0.158 to -0.025] 和 -0.022 [95% CI, -0.044 to -0.001]）。躯干和手臂内侧区域的参数保持稳定，只有皮肤弹性和疲劳效应呈现出与面部区域类似的改善趋势。这些变化早在 4 个月前就很明显：结论：口服 SPL 治疗痤疮不会损害皮肤屏障。结论：口服 SPL 治疗痤疮不会损害皮肤屏障，而且在 4 至 6 个月时，皮肤的机械性能得到了改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Dermatology 医学-皮肤病学

CiteScore

4.60

自引率

9.70%

发文量

368

审稿时长

4-8 weeks

期刊介绍： The Journal of Dermatology is the official peer-reviewed publication of the Japanese Dermatological Association and the Asian Dermatological Association. The journal aims to provide a forum for the exchange of information about new and significant research in dermatology and to promote the discipline of dermatology in Japan and throughout the world. Research articles are supplemented by reviews, theoretical articles, special features, commentaries, book reviews and proceedings of workshops and conferences. Preliminary or short reports and letters to the editor of two printed pages or less will be published as soon as possible. Papers in all fields of dermatology will be considered.