[Microbiological challenges in the treatment of war injuries].

Unfallchirurgie (Heidelberg, Germany) Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI:10.1007/s00113-024-01444-y
Dan Bieler, Erwin Kollig, Wolfgang Weber, Lisa Hackenberg, Florian Pavlu, Axel Franke, Benedikt Friemert, Gerhard Achatz
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Abstract

The treatment of war injuries represents a continuing and recurrent challenge in modern reconstructive surgery. Previously, tumor resections and sepsis-related resections were mainly responsible for lengthy bone defects in Germany. In recent years another picture has increasingly emerged, particularly caused by the medical support of Ukraine. Aspects of military surgery are also becoming more important in civil hospitals, especially in the treatment of gunshot and explosion injuries. In Germany, war injuries are currently secondarily treated, as the distribution of patients is carried out according to the cloverleaf principle, weeks or months after the occurrence of the primary injury. In addition to complex bone and soft tissue defects of the extremities following such injuries, which often affect neural and vascular structures, reconstruction is often complicated by an increasing spectrum of multidrug-resistant pathogens. The definition of microbiological terms, such as contamination, colonization, critical colonization, local and systemic infections are important in the clinical routine in order to initiate a targeted treatment, especially in treatment with antibiotics. Wound swabs for determination of the spectrum of pathogens and the optimal testing of resistance are important for selecting the appropriate antibiotic agents. The concept of antibiotic stewardship (ABS) is established in many hospitals to improve the quality of antibiotic treatment and to minimize the formation of resistance. The selection of the method of reconstruction depends on the condition of the patient, the overall clinical constellation and the function to be expected after completion of treatment. The treatment of injuries due to violence and terrorism necessitates clear concepts and an interdisciplinary approach, especially with respect to microbiological challenges and increasing resistance situations.

[战伤治疗中的微生物挑战]。
战伤治疗是现代整形外科面临的一项持续且反复出现的挑战。以前,在德国,漫长的骨缺损主要是由肿瘤切除和败血症相关切除造成的。近年来,另一种情况越来越多地出现,尤其是由乌克兰的医疗支持造成的。军事外科的一些方面在民用医院也变得越来越重要,尤其是在治疗枪伤和爆炸伤方面。在德国,战伤目前属于二级治疗,因为病人的分配是根据苜蓿叶原则进行的,即在原发性损伤发生数周或数月后。除了四肢复杂的骨骼和软组织缺损(通常会影响到神经和血管结构)外,重建工作往往还因越来越多的多重耐药病原体而变得复杂。在临床常规工作中,微生物术语的定义非常重要,如污染、定植、临界定植、局部和全身感染,以便启动有针对性的治疗,尤其是在使用抗生素治疗时。用伤口拭子确定病原体的谱系并对耐药性进行最佳检测,对于选择适当的抗生素制剂非常重要。许多医院都建立了抗生素监管(ABS)的概念,以提高抗生素治疗的质量,尽量减少耐药性的产生。重建方法的选择取决于患者的病情、整体临床情况以及治疗完成后的预期功能。治疗暴力和恐怖主义造成的伤害需要明确的概念和跨学科的方法,特别是在微生物挑战和耐药性不断增加的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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