Impact of immediate breast reconstruction on perioperative therapy: insights from a Japanese Nationwide Registry.

IF 4 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Cancer Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI:10.1007/s12282-024-01604-3

Shinsuke Sasada, Hiraku Kumamaru, Naoki Hayashi, Naoko Kinukawa, Masakazu Toi, Hiromitsu Jinno, Shigehira Saji

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引用次数: 0

Abstract

Background: Immediate breast reconstruction (IBR) is a common oncoplastic procedure used in breast cancer surgery. This study aims to investigate compliance with prosthetic breast reconstruction guidelines and its impact on perioperative treatment.

Methods: We reviewed data from the National Clinical Database-Breast Cancer Registry between January 2019 and December 2020. We compared perioperative treatment implementation between the IBR and non-IBR groups by subtype matching for age, menopausal status, T stage, N stage, and histology.

Results: A total of 8,860 patients with breast cancer who underwent IBR (6,075 breast prostheses, 2,492 autologous tissues, and 293 others) were identified. The compliance rate with the guidelines for prosthetic breast reconstruction was 97.7%. After matching, chemotherapy for luminal A-like diseases was significantly less frequent in the IBR group than in the non-IBR group (16.3% vs 20.5%, p < 0.001), and radiotherapy was less frequent in luminal A-like and HER2-positive patients (7.2% vs 9.0%, p = 0.010 and 7.1% vs 11.4%, p = 0.005, respectively). Among the 1-3 node-positive cases, fewer patients with prosthetic IBR received radiotherapy than those without IBR (15.7% vs 26.4%, p < 0.001).

Conclusion: Prosthetic breast reconstruction was performed with strict adherence to the Japanese guidelines. The implementation rates of chemotherapy and radiotherapy were lower in the specific IBR group than those in the non-IBR group. Therefore, large-scale, long-term follow-up data are required.

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即刻乳房再造对围术期治疗的影响：日本全国性登记的启示。

背景：即刻乳房重建（IBR）是乳腺癌手术中常用的肿瘤整形手术。本研究旨在调查假体乳房重建指南的合规性及其对围手术期治疗的影响：我们回顾了国家临床数据库--乳腺癌登记处在 2019 年 1 月至 2020 年 12 月期间的数据。我们通过年龄、绝经状态、T分期、N分期和组织学的亚型匹配，比较了IBR组和非IBR组的围手术期治疗实施情况：共发现8860名乳腺癌患者接受了IBR治疗（6075例乳房假体、2492例自体组织和293例其他）。假体乳房重建指南的符合率为 97.7%。经过比对，IBR 组因腔隙性 A 类疾病接受化疗的比例明显低于非 IBR 组（16.3% vs 20.5%，P 结论：IBR 组的化疗比例明显低于非 IBR 组（16.3% vs 20.5%，P 结论：IBR 组的化疗比例明显低于非 IBR 组）：假体乳房重建严格按照日本指南进行。特定 IBR 组的化疗和放疗实施率低于非 IBR 组。因此，需要大规模的长期随访数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.70

自引率

2.50%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Breast Cancer, the official journal of the Japanese Breast Cancer Society, publishes articles that contribute to progress in the field, in basic or translational research and also in clinical research, seeking to develop a new focus and new perspectives for all who are concerned with breast cancer. The journal welcomes all original articles describing clinical and epidemiological studies and laboratory investigations regarding breast cancer and related diseases. The journal will consider five types of articles: editorials, review articles, original articles, case reports, and rapid communications. Although editorials and review articles will principally be solicited by the editors, they can also be submitted for peer review, as in the case of original articles. The journal provides the best of up-to-date information on breast cancer, presenting readers with high-impact, original work focusing on pivotal issues.