Kidney failure from kidney stones: an ANZDATA study.

IF 4.8 2区医学 Q1 TRANSPLANTATION

Nephrology Dialysis Transplantation Pub Date : 2025-02-04 DOI:10.1093/ndt/gfae137

Hicham Cheikh Hassan, David J Tunnicliffe, Lyn Loyd, Adam Mullan, Ieuan Wickham, Brydee Cashmore, Matthew Jose, Andrew J Mallett

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引用次数: 0

Abstract

Background: Kidney stones are common, with an increasing trend over time, and have been well studied in the general population. However, the incidence and outcomes of kidney stones leading to kidney failure (KF) and the receipt of kidney replacement therapy (KRT) are poorly examined. We examined the incidence of KF due to kidney stones and compared outcomes with KRT patients due to other causes.

Methods: We studied adult patients who started KRT (January 1981-December 2020) and are included in the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. Exposure was KRT patients due to kidney stones, comparing them with patients with other causes. We examined incidence, prevalence, patient survival (KRT and transplant) and graft survival (transplant). Cox regression models were fitted to compare patient survival between the kidney stones and non-kidney stones groups, overall KRT, dialysis and patient and graft survival after kidney transplant.

Results: A total of 834 (1.1%) patients commenced KRT due to kidney stones. The incidence was 1.17 per million population per year and remained stable during the study period (annual change -0.3% [95% confidence interval (CI) -1.5-0.9]. Survival was higher in kidney stone patients receiving dialysis compared with the non-kidney stone group [hazard ratio (HR) 0.89 (95% CI 0.82-0.96)], with similar estimates in a matched cohort. In kidney transplant patients, time to transplant was longer for patients with kidney stones compared with non-kidney stone patients (2.5 versus 1.7 years; P = .001). There was no difference in mortality [HR 1.02 (95% CI 0.82-1.28)] or graft loss [HR 1.07 (95% CI 0.79-1.45)] between the kidney stones and non-kidney stones patients in the kidney transplant group.

Conclusion: The incidence of KF due to kidney stones was unchanged over the study period. Survival of patients with kidney stones who require KRT was better compared with patients with other causes. For the kidney transplant group, survival and risk of graft failure were similar.

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肾结石引起的肾衰竭：ANZDATA 登记研究

简介肾结石是一种常见病，且随着时间的推移呈上升趋势。然而，人们对肾结石导致肾衰竭（KF）和接受肾替代治疗（KRT）的发病率和结果却知之甚少。我们研究了肾结石导致肾衰竭的发病率，并将其结果与因其他原因导致肾衰竭的 KRT 患者进行了比较：研究对象为澳大利亚和新西兰透析与移植登记处（ANZDATA）登记的开始接受 KRT 治疗的成年患者（1981 年 1 月至 2020 年 12 月）。研究对象为因肾结石而接受 KRT 的患者，并将其与其他原因导致的患者进行比较。我们研究了发病率、流行率、患者存活率（KRT 和移植）和移植物存活率（移植）。通过拟合 Cox 回归模型，比较了肾结石组和非肾结石组患者的存活率、整体 KRT、透析以及肾移植后患者和移植物的存活率：共有 834 名（1.1%）患者因肾结石开始接受 KRT。发病率为每年每百万人口 1.17 例，在研究期间保持稳定（年百分比变化-0.3% [95%CI -1.5% 至 0.9%]）。与非肾结石组相比，接受透析治疗的肾结石患者的存活率更高（危险比 [HR]，0.89，95%CI 0.82-0.96），与匹配队列中的估计值相似。在肾移植患者中，与非肾结石患者相比，肾结石患者的移植时间更长（2.5 年 vs 1.7 年，P=0.001）。在肾移植组中，肾结石与非肾结石患者的死亡率（HR 1.02，95%CI 0.82-1.28）或移植物损失（HR 1.07，95%CI 0.79-1.45）没有差异：结论：肾结石导致的KF发生率在研究期间保持不变。结论：在研究期间，肾结石导致的 KF 发生率保持不变。与其他原因导致的 KF 相比，需要接受 KRT 的肾结石患者的存活率更高。肾移植组的存活率和移植失败的风险相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephrology Dialysis Transplantation 医学-泌尿学与肾脏学

CiteScore

10.10

自引率

4.90%

发文量

1431

审稿时长

1.7 months

期刊介绍： Nephrology Dialysis Transplantation (ndt) is the leading nephrology journal in Europe and renowned worldwide, devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. ndt is an official journal of the [ERA-EDTA](http://www.era-edta.org/) (European Renal Association-European Dialysis and Transplant Association). Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world. All research articles in this journal have undergone peer review. Print ISSN: 0931-0509.