Rising Mortality among Non-Hispanics due to Pancreatic Cancer in the United States. A CDC Database analysis.

IF 1.6 Q4 ONCOLOGY
Journal of Gastrointestinal Cancer Pub Date : 2024-09-01 Epub Date: 2024-06-18 DOI:10.1007/s12029-024-01084-w
Samar Mahmood, Hafiz Muhammad Sameer, Arooba Ejaz, Syed Muhammad Ahsan, Urooj Mazhar, Komal Zulfiqar
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引用次数: 0

Abstract

Purpose: To examine mortality trends among non-Hispanic (NH) adults with pancreatic cancer.

Method: CDC-WONDER database was used to extract death certificate data on pancreatic cancer-related mortality in NH adults aged ≥ 45 from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent changes (APCs) were calculated and stratified by year, age, sex, race, and region.

Results: From 1999 to 2020, 783,772 deaths occurred among middle-aged (45-64) and older (65-85 +) NH adults. Overall AAMR increased from 31.7 in 1999 to 33.8 in 2020 (APC: 0.35; 95% CI:0.28-0.41). NH older adults had higher AAMRs (67.9) than NH middle-aged adults (12.5). Men consistently had higher AAMRs (37.7) than women (28.4). NH African Americans had the highest AAMRs (40.8) compared to NH Whites (32.1), NH American Indians (23.9), and NH Asians (22.4). Metropolitan areas had a higher AAMR (32.7) than non-metropolitan areas (32.2). The Northeast region had the highest AAMR (34.0) followed by Midwest (33.2), South (32.2), and West (30.1). Delaware, District of Columbia, Louisiana, Michigan, and Mississippi had the highest AAMRs among states.

Conclusions: Pancreatic cancer-related mortality among NH adults has increased from 1999 to 2020. Highest AAMRs were reported in older men, NH African Americans, the Northeastern and metropolitan areas.

美国非西班牙裔胰腺癌死亡率上升。疾病预防控制中心数据库分析。
目的:研究非西班牙裔(NH)成人胰腺癌患者的死亡率趋势:使用 CDC-WONDER 数据库提取 1999 年至 2020 年期间年龄≥ 45 岁的 NH 成年人胰腺癌相关死亡率的死亡证明数据。计算每 10 万人的年龄调整死亡率(AAMRs)和年百分比变化率(APCs),并按年份、年龄、性别、种族和地区进行分层:从 1999 年到 2020 年,有 783,772 例死亡发生在中年(45-64 岁)和老年(65-85 岁以上)的北卡罗来纳州成年人中。总体AAMR从1999年的31.7上升到2020年的33.8(APC:0.35;95% CI:0.28-0.41)。新罕布什尔州老年人的急性心肌梗死死亡率(67.9)高于新罕布什尔州中年人(12.5)。男性的 AAMRs(37.7)始终高于女性(28.4)。与新罕布什尔州白人(32.1)、新罕布什尔州美国印第安人(23.9)和新罕布什尔州亚洲人(22.4)相比,新罕布什尔州非洲裔美国人的 AAMRs(40.8)最高。大都市地区的 AAMR(32.7)高于非大都市地区(32.2)。东北地区的 AAMR 最高(34.0),其次是中西部(33.2)、南部(32.2)和西部(30.1)。特拉华州、哥伦比亚特区、路易斯安那州、密歇根州和密西西比州的AAMR最高:结论:从 1999 年到 2020 年,新罕布什尔州成年人中与胰腺癌相关的死亡率有所上升。据报告,年龄较大的男性、新罕布什尔州非裔美国人、东北部地区和大都会地区的急性胰腺癌死亡率最高。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
121
期刊介绍: The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology:  This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.
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