Pancreas-specific immune-related adverse events in patients with lung cancer: a case series study.

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-01-01 Epub Date: 2024-06-18 DOI:10.1080/1750743X.2024.2354108

Liu Jia, Shi Yuequan, Fang Jian, Lu Hongmin, Shui Yongjie, Liu Xiaoyan, Chen Minjiang, Xu Yan, Wang Mengzhao

引用次数: 0

Abstract

Immune-related adverse events (irAEs) are one of the key concerns in cancer patients treated with immune checkpoint inhibitors (ICIs). Among the various irAEs, pancreas-specific irAE is a rare but special one with a variety of manifestations, such as pancreatic enzymes elevation, pancreatitis as well as diabetes. The current study reported 22 pancreas-specific irAEs in 21 patients with lung cancer, including pancreatic injury in 13 patients, pancreatitis in four patients and diabetes mellitus in five patients.

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肺癌患者胰腺特异性免疫相关不良事件：病例系列研究。

免疫相关不良事件（irAEs）是接受免疫检查点抑制剂（ICIs）治疗的癌症患者关注的焦点之一。在各种irAEs中，胰腺特异性irAEs是一种罕见但特殊的irAEs，其表现多种多样，如胰酶升高、胰腺炎和糖尿病等。本研究报告了 21 例肺癌患者中的 22 例胰腺特异性虹吸效应，包括 13 例患者的胰腺损伤、4 例患者的胰腺炎和 5 例患者的糖尿病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.