Study use of Interferon Gamma-Induced Protein 10 Kda and C-Reactive Protein as Diagnostic Markers for Spontaneous Bacterial Peritonitis

Abstract

years while in non-SBP patients was 62.62 ± 8.76 years. Ascitic fluid CRP and IP-10 levels were significantly higher in SBP patients than in non-SBP patients (1.45 ± 0.16 vs. 1.08 ± 0.2 mg/L; P<0.001 and 1794.33 ± 175.65 vs. 1451.06 ± 178.78 pg/ml; P<0.001), respectively. At a cut-off value of 1.25 mg/L, ascitic fluid CRP had a sensitivity of 95.6% and a specificity of 80.0% for detection of SBP (area under the curve: 0.931). A cut-off value of 1619.3 pg/ml, ascitic fluid IP-10 had a sensitivity of 91.1% and a specificity of 80.0% for detection of SBP (area under the curve: 0.907). Both correlated with ascitic polymorphonuclear count and serum CRP. Conclusion: Ascitic fluid levels of CRP and IP-10 seem to represent satisfactory adjunction in diagnosis of SBP.