The effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-06-06 DOI:10.1016/j.jdiacomp.2024.108780

Sadegh Mozaffari , Mahdeyeh Aliari , Solaleh Emamgholipour , Hossein Hosseini , Pedram Rezaei Amirkiasar , Mina Zare , Niki Katsiki , Ghodratollah Panahi , Amirhossein Sahebkar

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引用次数: 0

Abstract

Background-aim

Non-alcoholic fatty liver disease (NAFLD¹) is the most frequent chronic liver disorder worldwide. Currently, no pharmacological treatment has been approved for NAFLD. Probiotics have been suggested as a potential therapy for NAFLD. The aim of this systematic review and meta-analysis was to assess the impact of probiotic intake on liver tests, lipids, glycemic parameters and inflammatory markers in NAFLD patients.

Methods

We searched electronic databases using related terms. Meta-analysis was performed using random-effects models. Clinical outcomes were presented as standard mean difference (SMD²) with a 95 % confidence interval (CI³). Publication bias and heterogeneity were evaluated in eligible studies.

Results

Fifteen randomized clinical trials comprising 899 participants were included in our meta-analysis. Probiotic supplementation improved alanine transaminase [SMD -0.796; 95 % CI (−1.419, −0.172); p = 0.012], Homeostatic Model Assessment for Insulin Resistance (HOMA-IR⁴) [SMD -0.596; 95 % CI (−1.071, −0.121); p = 0.01] and insulin levels [SMD -1.10; 95 % CI (−2.121, −0.087); p = 0.03]. No significant effects were observed on fasting glucose, hemoglobin A1c, aspartate transaminase, lipid profile, interleukin-6 and tumor necrosis factor-α.

Conclusions

Probiotic intake may improve insulin sensitivity and alanine transaminase in NAFLD patients.

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食用益生菌对非酒精性脂肪肝患者血脂状况、血糖指数、炎症指标和肝功能的影响：随机对照试验的系统回顾和荟萃分析

背景-目的非酒精性脂肪肝（NAFLD1）是全球最常见的慢性肝病。目前，非酒精性脂肪肝的药物治疗尚未获得批准。益生菌被认为是治疗非酒精性脂肪肝的一种潜在疗法。本系统综述和荟萃分析旨在评估摄入益生菌对非酒精性脂肪肝患者肝脏检查、血脂、血糖参数和炎症指标的影响。采用随机效应模型进行元分析。临床结果以标准平均差 (SMD2) 和 95 % 置信区间 (CI3) 表示。对符合条件的研究进行了发表偏倚和异质性评估。结果我们的荟萃分析纳入了 15 项随机临床试验，共有 899 名参与者。补充益生菌可改善丙氨酸转氨酶[SMD -0.796；95 % CI (-1.419, -0.172)；p = 0.012]、胰岛素抵抗稳态模型评估（HOMA-IR4）[SMD -0.596；95 % CI (-1.071, -0.121)；p = 0.01]和胰岛素水平[SMD -1.10；95 % CI (-2.121, -0.087)；p = 0.03]。结论摄入益生菌可改善非酒精性脂肪肝患者的胰岛素敏感性和丙氨酸转氨酶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.