Memory Consolidation and Sleep in Children With Epilepsy: A Systematic Review

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2024-06-07 DOI:10.1016/j.pediatrneurol.2024.05.020

Sebastian Hoyer MA , Marie Dietz MS , Anna-Sophie Ambrosi-Schneider , Nadashree Krishnasamy , Claudia Buss Prof. Dr. , Yee Lee Shing Prof. Dr. , Angela M. Kaindl Prof. Dr.

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Abstract

Background

Sleep is essential in the process of memory consolidation. Children and adolescents with epilepsy hold a significantly higher risk for memory impairment. Understanding the relationship between sleep and memory impairment in adolescents with epilepsy will help us to develop effective support services for this patient population. The present study provides a summary of the current research on the influence of epilepsy-related altered sleep patterns on memory consolidation in children and adolescents with epilepsy. The aim of this systematic review is to investigate the influence of epilepsy-related altered sleep conditions in children and adolescents and their impact on memory performance.

Materials

A systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses using the search terms "memory," "sleep," "epilepsy," "children," and "adolescents." A total of 4 studies met the inclusion criteria. The review focused on the association of sleep disorders and memory performance in children and adolescents aged up to 21 years without psychiatric comorbidities.

Results

The reviewed studies highlight a higher risk of sleep disturbance and lower sleep quality in children with epilepsy in comparison to control groups. Group differences in memory consolidation were found before, but not after one night of sleep. Three studies reported a significant association between sleep and memory performance. Two studies demonstrated an association between nocturnal interictal epileptiform discharges and memory performance in adolescents.

Conclusion

Children and adolescents with epilepsy have a higher risk of sleep and memory disorders. Nocturnal interictal epileptiform discharges have been shown to interfere with memory consolidation. Conclusions on underlying mechanisms remain unclear. Further case-control studies addressing sleep and its influence on memory problems in pediatric epilepsy patients are needed.

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癫痫儿童的记忆巩固与睡眠，一项系统性综述

背景睡眠在记忆巩固过程中至关重要。儿童和青少年癫痫患者出现记忆障碍的风险明显更高。了解青少年癫痫患者的睡眠与记忆障碍之间的关系将有助于我们为这一患者群体开发有效的支持服务。本研究总结了目前关于与癫痫相关的睡眠模式改变对儿童和青少年癫痫患者记忆巩固的影响的研究。本系统性综述旨在研究儿童和青少年癫痫相关睡眠条件改变对记忆表现的影响。材料根据《系统性综述和元分析首选报告项目》的指导原则，使用 "记忆"、"睡眠"、"癫痫"、"儿童 "和 "青少年 "等检索词进行了系统性综述。共有 4 项研究符合纳入标准。综述的重点是21岁以下无精神疾病合并症的儿童和青少年的睡眠障碍与记忆表现之间的关系。结果综述研究显示，与对照组相比，癫痫患儿出现睡眠障碍的风险更高，睡眠质量更低。研究发现，在一夜睡眠之前，记忆巩固方面存在群体差异，但在一夜睡眠之后则没有。三项研究报告了睡眠与记忆表现之间的重要关联。结论患有癫痫的儿童和青少年出现睡眠和记忆障碍的风险较高。夜间发作间期癫痫样放电已被证明会干扰记忆的巩固。有关其潜在机制的结论仍不明确。需要进一步开展病例对照研究，探讨睡眠及其对小儿癫痫患者记忆问题的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.