AVM: A Manually Curated Database of Aerosol-transmitted Virus Mutations, Human Diseases, and Drugs

Abstract

Aerosol-transmitted viruses possess strong infectivity and can spread over long distances, earning the difficult-to-control title. They cause various human diseases and pose serious threats to human health. Mutations can increase the transmissibility and virulence of the strains, reducing the protection provided by vaccines and weakening the efficacy of antiviral drugs. To this end, in this study, we aimed to establish a manually curated database (AVM) to store information regarding viral mutations (VMs). The current version of the AVM contains 42,041 VMs, including 2613 immune escape mutations, 45 clinical information datasets, and 407 drugs, antibodies, or vaccines. Additionally, we recorded 88 human diseases associated with viruses and found that the same virus can target multiple organs in the body, leading to diverse diseases. Furthermore, the AVM database offers a straightforward user interface for browsing, retrieving, and downloading information. We believe that this database is a comprehensive resource that can provide timely and valuable information regarding the transmission, treatment, and diseases caused by aerosol-transmitted viruses (http://www.bio-bigdata.center/AVM).