Medical hypnosis on depression and interleukin-6 levels in lung cancer patients

International Journal of Research in Medical Sciences Pub Date : 2024-06-06 DOI:10.18203/2320-6012.ijrms20241602

Wijaya Kusuma, Ardi Andriatno, Budhi Hami Seno

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Abstract

Background: Lung cancer patients are at high risk for depression, which is associated with poor treatment adherence. Medical hypnosis can improve symptoms of depression and affect interleukin-6 levels. This study aims to determine the effectiveness of medical hypnosis in improving depression and reducing IL-6 levels in lung cancer patients. Methods: This study is a quasi-experimental study with a pretest and post-test control group design. It assessed depressive symptoms using BDI-II scores and serum IL-6 levels in an intervention group receiving medical hypnosis and standard therapy compared to a control group receiving standard therapy. Data analysis was conducted using univariate tests, followed by Pearson correlation tests and effect size measurement with Cohen's d test. Results: The Wilcoxon test showed a decrease in IL-6 levels in the intervention group by 14.66±19.45 (p=0.008) and a reduction in BDI-II scores by 8.26±4.78 (p=0.001). Correlation tests indicated a significant relationship between IL-6 levels and BDI-II scores (r=0.472; p=0.009). Cohen's d test showed the effect size of medical hypnosis on IL-6 levels was 0.754 (moderate=0.5

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医学催眠对肺癌患者抑郁和白细胞介素-6水平的影响

背景：肺癌患者患抑郁症的风险很高，而抑郁症与治疗依从性差有关。医学催眠可以改善抑郁症状并影响白细胞介素-6水平。本研究旨在确定医学催眠在改善肺癌患者抑郁和降低 IL-6 水平方面的效果：本研究是一项准实验研究，采用前测和后测对照组设计。与接受标准疗法的对照组相比，接受医学催眠和标准疗法的干预组使用BDI-II评分评估抑郁症状，并评估血清IL-6水平。数据分析采用单变量检验，然后进行皮尔逊相关检验，并用科恩氏d检验测量效应大小：Wilcoxon检验显示，干预组的IL-6水平降低了14.66±19.45（P=0.008），BDI-II评分降低了8.26±4.78（P=0.001）。相关测试表明，IL-6 水平与 BDI-II 评分之间存在显著关系（r=0.472；p=0.009）。Cohen's d检验显示，医学催眠对IL-6水平的效应大小为0.754（中度=0.5

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International Journal of Research in Medical Sciences

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