Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain

Abstract

The presence of neuronal amyloid β (Aβ) plaques and neurofibrillary tangles are the main indicators of Alzheimer’s disease (AD) and Parkinson’s disease (PD), which are the most common neurological diseases of old age. It is obvious that the existing and developed treatments are not able to change the conditions and cure these diseases, so the development of preventive therapeutic interventions without complications seems necessary. Clinical findings indicate that oxidative stress and neurotoxicity caused by amyloid β (Aβ) play a fundamental role in the pathogenesis of Alzheimer’s disease (AD). Among a wide range of medicinal compounds studied for the treatment and prevention of neurological diseases, Nobiletin (NOB)has been the focus of researchers. NOB is a bioflavonoid isolated from citrus peel that has anti-inflammatory, antioxidant and anti-dementia properties and the ability to improve intracellular and extracellular antibodies. In this study, the neuroprotective effects of NOB against Aβ-induced neurotoxicity discovered in the last decade were discussed. The molecular mechanisms involved have also been considered.