Stereological and behavioural analysis reveals the better neuroprotective effect of cinnamaldehyde than berberine chloride in a rat model of global cerebral ischemia

Traditional & Kampo Medicine Pub Date : 2024-06-07 DOI:10.1002/tkm2.1413

Dariush Mehboodi, Abbas Shahedi, Mohammadreza Namavar, Fatemeh Zakizadeh, Arezoo Teymoori

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Abstract

Global cerebral ischemia (GCI) is characterized by the hindrance of blood flow to the brain due to obstruction in the carotid arteries. In this study, the neuroprotective effects of berberine chloride (BBR) and cinnamaldehyde (CA) against GCI in male Wistar rats were investigated, and their efficacy was compared.Twenty‐four rats were randomly assigned to four groups: Sham, GCI, GCI + BBR, and GCI + CA. 100 mg/kg of BBR and CA were administered five minutes and six hours after inducing GCI by occluding two common carotids for 20 minutes.The findings showed that both compounds mitigated GCI‐induced damage to the hippocampus and its subfields, and CA demonstrated better neuroprotective efficacy than BBR. These results was also supported by behavioural tests, which revealed better memory function in GCI + CA compared to GCI + BBR.The study showed the neuroprotective impact of CA and BBR against GCI, and CA emerged as a more effective therapeutic agent against GCI‐induced damage. Further research is necessary to uncover the specific mechanisms behind these differences.

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立体学和行为分析表明，在大鼠全脑缺血模型中，肉桂醛比氯化小檗碱具有更好的神经保护作用

全脑缺血（GCI）的特征是颈动脉阻塞导致脑血流受阻。本研究探讨了氯化小檗碱（BBR）和肉桂醛（CA）对雄性 Wistar 大鼠 GCI 的神经保护作用，并比较了它们的功效：24 只大鼠被随机分为四组：Sham 组、GCI 组、GCI + BBR 组和 GCI + CA 组。研究结果表明，两种化合物都能减轻 GCI 对海马及其亚场的损伤，而 CA 的神经保护效果优于 BBR。这些结果也得到了行为测试的支持，行为测试显示，与 GCI + BBR 相比，GCI + CA 具有更好的记忆功能。该研究表明，CA 和 BBR 对 GCI 具有神经保护作用，CA 是一种对 GCI 引起的损伤更有效的治疗药物。要揭示这些差异背后的具体机制，还需要进一步的研究。

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Traditional & Kampo Medicine

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