Perbedaan Aktivitas Antimalaria Citrus maxima, Anredera cordifolia, Kombinasi Solanum lycopersicum-Malus domestica-Daucus carota pada Mencit Diinfeksi Plasmodium berghei)

Abstract

Malaria drug resistance, both new and old drugs, causes severe symptoms and treatment failure. In order to develop new drug, we screen several plants that potentially used as antimalaria. This study aimed to screen and compare antimalaria activity of Citrus maxima, Anredera cordifolia, Solanum lycopersicum, combination Solanum lycopersicum-Malus domestica-Daucus carota in a mouse model. Balb/ c mice male were divided into six groups (n=5). The dried plants were extracted by maceration using 80% methanol. A 4-day suppressive test was done to ascertain the anti-plasmodial effect of those various plants. After inoculation with Plasmodium berghei, the treatment groups were given 1000 mg/kg of the extract, while 5% RPMI and DHP (Dihydroartemisinine Piperaquine) served as controls. The results of this study revealed that all extracts showed significantly lower parasitemia compared to the negative control. This study showed a percentage parasite suppression of 58.7, 84.3, 77.4, 61.4 and 83.9 % for Anredera cordifolia, Citrus maxima, Solanum lycopersicum, combination Solanum lycopersicum-Malus domestica-Daucus carota and Dihydroartemisinine Piperaquine, respectively. The highest parasite suppression (84.3%) was found in the group given Citrus maxima extract. This study concluded that the fruit extract of Citrus Maxima, Anredera Cordifolia, Solanum Lycopersicum-Malus Domestica-Daucus Carota have different antimalaria activity, Citrus maxima has the best potential as an antimalarial.