{"title":"Construction and Properties of Strong Near-IR Absorption Photosensitizers","authors":"Fei Cheng, Taotao Qiang, Tony D. James","doi":"10.1002/adom.202401012","DOIUrl":null,"url":null,"abstract":"<p>The design of near-infrared photosensitizers with high photodynamic and photothermal synergistic therapeutic properties is of great significance for tumor therapy. In this study, An-cyclic-BDP with excellent near-infrared absorption (<i>ε</i> = 1.94 × 10<sup>5</sup> <span>m</span><sup>−1 </sup>cm<sup>−1</sup> at 804 nm) is prepared using a dual strategy of twisted π-conjugated system induction (T-π-CSI) and spin-orbit charge transfer (SOCT). Theoretical calculations, steady-state and transient absorption spectra are used to investigate the intrinsic regulatory mechanisms between molecular structure and intersystem crossing (ISC) capacity. The results indicate that the application of the T-π-CSI and SOCT approach can be superimposed to increase ISC capacity and the triplet lifetime of An-cyclic-BDP (τ = 2961 ps). Electron paramagnetic resonance (EPR) results confirm that An-cyclic-BDP has the ability to generate hydroxyl radical (·OH) and singlet oxygen (<sup>1</sup>O<sub>2</sub>). Furthermore, the calculated <sup>1</sup>O<sub>2</sub> yield of An-cyclic-BDP is found to be 13%. The experimental results of the photothermal conversion indicates that An-cyclic-BDP exhibits a photothermal conversion efficiency of up to 48%. In vitro cell experiments demonstrate that An-cyclic-BDP-NPs, constructed by encapsulating An-cyclic-BDP with DSPE-mPEG<sub>2000</sub>, exhibit excellent biocompatibility and tumor cell-killing ability. Therefore, the strong near-IR absorption photosensitizer prepared in this study exhibits significant potential for application in the area of photodynamic and photothermal synergistic therapy.</p>","PeriodicalId":116,"journal":{"name":"Advanced Optical Materials","volume":null,"pages":null},"PeriodicalIF":8.0000,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adom.202401012","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Optical Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adom.202401012","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The design of near-infrared photosensitizers with high photodynamic and photothermal synergistic therapeutic properties is of great significance for tumor therapy. In this study, An-cyclic-BDP with excellent near-infrared absorption (ε = 1.94 × 105m−1 cm−1 at 804 nm) is prepared using a dual strategy of twisted π-conjugated system induction (T-π-CSI) and spin-orbit charge transfer (SOCT). Theoretical calculations, steady-state and transient absorption spectra are used to investigate the intrinsic regulatory mechanisms between molecular structure and intersystem crossing (ISC) capacity. The results indicate that the application of the T-π-CSI and SOCT approach can be superimposed to increase ISC capacity and the triplet lifetime of An-cyclic-BDP (τ = 2961 ps). Electron paramagnetic resonance (EPR) results confirm that An-cyclic-BDP has the ability to generate hydroxyl radical (·OH) and singlet oxygen (1O2). Furthermore, the calculated 1O2 yield of An-cyclic-BDP is found to be 13%. The experimental results of the photothermal conversion indicates that An-cyclic-BDP exhibits a photothermal conversion efficiency of up to 48%. In vitro cell experiments demonstrate that An-cyclic-BDP-NPs, constructed by encapsulating An-cyclic-BDP with DSPE-mPEG2000, exhibit excellent biocompatibility and tumor cell-killing ability. Therefore, the strong near-IR absorption photosensitizer prepared in this study exhibits significant potential for application in the area of photodynamic and photothermal synergistic therapy.
期刊介绍:
Advanced Optical Materials, part of the esteemed Advanced portfolio, is a unique materials science journal concentrating on all facets of light-matter interactions. For over a decade, it has been the preferred optical materials journal for significant discoveries in photonics, plasmonics, metamaterials, and more. The Advanced portfolio from Wiley is a collection of globally respected, high-impact journals that disseminate the best science from established and emerging researchers, aiding them in fulfilling their mission and amplifying the reach of their scientific discoveries.