Cognitive-motor interference in multiple sclerosis and healthy controls: results from single, dual, and triple task posturography

Patrik Althoff, Friederike Rosenthal, Eva-Maria Dorsch, Daniel Drebinger, Radina Arsenova, Anna Chorschew, S. Rosenkranz, J. Bellmann-Strobl, Christoph Heesen, Friedemann Paul, M. Weygandt, Tanja Schmitz-Hübsch
{"title":"Cognitive-motor interference in multiple sclerosis and healthy controls: results from single, dual, and triple task posturography","authors":"Patrik Althoff, Friederike Rosenthal, Eva-Maria Dorsch, Daniel Drebinger, Radina Arsenova, Anna Chorschew, S. Rosenkranz, J. Bellmann-Strobl, Christoph Heesen, Friedemann Paul, M. Weygandt, Tanja Schmitz-Hübsch","doi":"10.37349/ent.2024.00082","DOIUrl":null,"url":null,"abstract":"Aim: This article is based on our previous research, which was presented as a poster at the ECTRIMS Congress 2018 and published as a conference abstract (https://www.professionalabstracts.com/ectrims2018/iplanner/#/presentation/1698). Cognitive-motor interference (CMI) has been observed in both healthy controls (HC) and persons with multiple sclerosis (pwMS), but limited and contradictory data is making it difficult to assess the impact of motor and cognitive functioning levels on CMI. The aim of this study was to investigate CMI in pwMS and HC by means of a dual task postural paradigm, to compare them between groups and to analyse the influence of motor and cognitive functioning levels assessed with complementary instruments on observed CMI. Methods: The dual task posturography paradigm serves to quantify the impact of a cognitive (i.e., performing serial subtractions), a motor challenge (closing eyes), or both challenges combined (triple task) on body sway during standing in an upright position feet closed. The data analysed were acquired in one interventional and four observational studies and selected based on predefined criteria and by systematic quality control. A total of 113 pwMS and 42 HC were selected for analysis. Results: Comparable changes in motor and cognitive performance due to cognitive or combined cognitive-motor challenges were observed in both HC and pwMS. Combining both tasks did not result in further changes in motor performance but resulted in a decrease in cognitive performance. This reduction in cognitive performance with an additional motor challenge correlated with lower levels of cognitive and motor functioning in pwMS. Unexpectedly, an increase in body sway due to a cognitive or combined cognitive-motor challenges was primarily observed in pwMS and HC with better cognitive and motor functioning. Conclusions: The results suggest that dual-task effects are not disease-specific but rather reflect individually different adaptation strategies depending on the specific motor and cognitive functioning levels.","PeriodicalId":502664,"journal":{"name":"Exploration of Neuroprotective Therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration of Neuroprotective Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37349/ent.2024.00082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Aim: This article is based on our previous research, which was presented as a poster at the ECTRIMS Congress 2018 and published as a conference abstract (https://www.professionalabstracts.com/ectrims2018/iplanner/#/presentation/1698). Cognitive-motor interference (CMI) has been observed in both healthy controls (HC) and persons with multiple sclerosis (pwMS), but limited and contradictory data is making it difficult to assess the impact of motor and cognitive functioning levels on CMI. The aim of this study was to investigate CMI in pwMS and HC by means of a dual task postural paradigm, to compare them between groups and to analyse the influence of motor and cognitive functioning levels assessed with complementary instruments on observed CMI. Methods: The dual task posturography paradigm serves to quantify the impact of a cognitive (i.e., performing serial subtractions), a motor challenge (closing eyes), or both challenges combined (triple task) on body sway during standing in an upright position feet closed. The data analysed were acquired in one interventional and four observational studies and selected based on predefined criteria and by systematic quality control. A total of 113 pwMS and 42 HC were selected for analysis. Results: Comparable changes in motor and cognitive performance due to cognitive or combined cognitive-motor challenges were observed in both HC and pwMS. Combining both tasks did not result in further changes in motor performance but resulted in a decrease in cognitive performance. This reduction in cognitive performance with an additional motor challenge correlated with lower levels of cognitive and motor functioning in pwMS. Unexpectedly, an increase in body sway due to a cognitive or combined cognitive-motor challenges was primarily observed in pwMS and HC with better cognitive and motor functioning. Conclusions: The results suggest that dual-task effects are not disease-specific but rather reflect individually different adaptation strategies depending on the specific motor and cognitive functioning levels.
多发性硬化症和健康对照组的认知运动干扰:单任务、双任务和三任务体位测量法的结果
目的:本文基于我们之前的研究,该研究曾在2018年ECTRIMS大会上以海报形式展示,并以会议摘要形式发表(https://www.professionalabstracts.com/ectrims2018/iplanner/#/presentation/1698)。在健康对照组(HC)和多发性硬化症患者(pwMS)中都观察到了认知运动干扰(CMI),但由于数据有限且相互矛盾,因此很难评估运动和认知功能水平对 CMI 的影响。本研究的目的是通过双任务姿势范式调查多发性硬化症患者和健康对照组的 CMI,在组间进行比较,并分析用互补工具评估的运动和认知功能水平对观察到的 CMI 的影响。研究方法双任务姿势测量范式用于量化认知挑战(即进行连续减法)、运动挑战(闭眼)或两种挑战相结合(三重任务)对双脚闭合直立时身体摇摆的影响。所分析的数据来自一项干预性研究和四项观察性研究,并根据预定标准和系统质量控制进行筛选。共选取了 113 名重症肌无力患者和 42 名高血压患者的数据进行分析。研究结果在认知挑战或认知-运动挑战相结合的情况下,运动和认知能力都发生了类似的变化。将两项任务结合在一起不会导致运动表现的进一步变化,但会导致认知表现的下降。认知能力的下降与额外的运动挑战有关,而认知能力的下降又与 pwMS 较低的认知和运动功能水平有关。出乎意料的是,认知挑战或认知-运动联合挑战导致的身体摇摆增加主要出现在认知和运动功能较好的 pwMS 和 HC 中。结论研究结果表明,双任务效应并不是疾病的特异性,而是根据具体的运动和认知功能水平反映出各自不同的适应策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信