Integration Of Acoustophoresis and Dielectrophoresis on A Single Chip Platform: A Numerical Study

Anjam Waheed, M. R. Buyong, M. F. Mohd, Razip Wee
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Abstract

Passive or active manipulation forces would be needed for the microfluidic system for chemical and biological analysis in order to regulate, trap, separate, sort, and discriminate between particles and cells. The primary goals of passive manipulation are consistency and repeatability to attain high levels of control with exact trajectories. In the meantime, by introducing external forces like hydrodynamic, dielectrophoretic, magnetophoretic, acoustophoretic, and optical tweezing, the active manipulations allow to control particle displacement in a highly predictable and consistent fashion. These methods are much more promising for the development of a small and compact biomedical diagnostic rapid test. Since most biological particles are suspended in different biological fluids like blood and urine, dielectrophoresis (DEP) and acoustophoresis (ACP) have been demonstrated to be promising among these external forces because of their ability to apply forces on the particles in a liquid environment. Additionally, both techniques are fast, inexpensive to fabricate, label-free, and incredibly selective. In this study, we introduce a novel method that combines these two forces into a single chip, improving the separation process for ACP and DEP based on the intrinsic dielectric and acoustic properties of the particles, respectively. It is anticipated that this research would shed light on why particular manipulative factors predominate more or less in particular situations.
在单芯片平台上集成声泳和介电泳:数值研究
用于化学和生物分析的微流体系统需要被动或主动操纵力,以调节、捕获、分离、分类和区分颗粒和细胞。被动操纵的主要目标是一致性和可重复性,以实现精确轨迹的高水平控制。与此同时,通过引入外力,如流体动力、介电泳、磁泳、声泳和光学镊子等,主动操作可以以高度可预测和一致的方式控制粒子位移。这些方法对于开发体积小、结构紧凑的生物医学诊断快速检测仪更有前途。由于大多数生物微粒都悬浮在血液和尿液等不同的生物液体中,介质电泳(DEP)和声波电泳(ACP)因能在液体环境中对微粒施力,已被证明在这些外力中很有前途。此外,这两种技术制造快速、成本低廉、无需标记,而且选择性极强。在本研究中,我们引入了一种新方法,将这两种力结合到一个芯片中,分别根据颗粒的固有介电特性和声学特性改进 ACP 和 DEP 的分离过程。预计这项研究将揭示为什么在特定情况下,特定的操纵因素或多或少地占主导地位。
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