Chemistry or Hypoglycaemic Aspect of Thiazolidin-2,4-Dione Insight into the Structure-activity Relationship

Q2 Pharmacology, Toxicology and Pharmaceutics
Parvinder Kaur, Nitin Kumar, Shikha Sharma, B. Banik
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引用次数: 0

Abstract

Heterocyclic compounds that incorporate nitrogen and sulfur, particularly those within the thiazole family, have garnered significant attention due to their versatile synthetic properties. This interest arises from their abundance of biologically active natural products and their effectiveness as potent agrochemicals and pharmaceuticals. Among these, the thiazolidin-2,4-dione (TZD) motif plays a pivotal role in the biological functions of many important molecules. The adaptability of the TZD scaffold is further heightened by the potential for substitutions at the third and fifth positions, rendering it a widely employed moiety with diverse biological effects. TZD analogs, bearing substitutions at these positions, exhibit a wide spectrum of biological activities, with a notable emphasis on hypoglycemic effects attributed to enhanced insulin resistance through the activation of the PPAR-γ receptor. This manuscript aims to present a comprehensive review of research conducted on TZD derivatives as potential antihyperglycemic agents spanning from 2010 to the current date. The review encompasses insights into their molecular mechanisms. Thiazolidin-based chemicals have received significant attention as hypoglycemic agents and provided information on patents granted for TZD analogs.
噻唑烷-2,4-二酮的化学或降血糖作用对结构-活性关系的启示
含有氮和硫的杂环化合物,尤其是噻唑家族的杂环化合物,因其多用途的合成特性而备受关注。其中,噻唑啉-2,4-二酮(TZD)基团在许多重要分子的生物功能中发挥着关键作用。TZD 支架的适应性因第三位和第五位的潜在取代而进一步提高,使其成为具有多种生物效应的广泛应用分子。在这些位置上发生取代的 TZD 类似物具有广泛的生物活性,尤其是通过激活 PPAR-γ 受体增强胰岛素抵抗力而产生的降血糖作用。本手稿旨在对 2010 年至今有关 TZD 衍生物作为潜在降血糖药物的研究进行全面综述。噻唑烷类化学品作为降血糖药物受到了广泛关注,并提供了有关 TZD 类似物专利的信息。
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来源期刊
Current Bioactive Compounds
Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.90
自引率
0.00%
发文量
112
期刊介绍: The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.
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