Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough?

Mi-Yeong Kim, Ha-Kyeong Won, Ji-Yoon Oh, Ji-Hyang Lee, Eun-Jung Jo, Sung-Yoon Kang, Ji-Ho Lee, Seung-Eun Lee, N. Kang, Young-Chan Kim, Hwa Young Lee, J. An, Y. Yoo, J.-S. Shim, So-Young Park, H. Park, Min-Hye Kim, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Sang-Hoon Kim, Byung Jae Lee, S. Birring, Woo-Jung Song
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Abstract

The symptoms of cough hypersensitivity do not distinguish between asthmatic cough and refractory chronic cough. Cough reflex hypersensitivity may underlie chronic cough across different phenotypes, despite having different treatable traits,Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic cough. This study aimed to compare symptom features, such as cough triggers and associated throat sensations, of cough hypersensitivity in patients with asthmatic chronic cough and those with refractory chronic cough (RCC).Patients with chronic cough from the Korean Chronic Cough Registry were prospectively evaluated over 6 months. Physicians determined the etiological diagnosis based on clinical evaluations and responses to treatment at the 6-month follow-up visit. Symptoms of cough hypersensitivity and cough-specific quality of life were assessed using the Cough Hypersensitivity Questionnaire (CHQ) and the Leicester Cough Questionnaire (LCQ), respectively.The analysis included 280 patients who completed the follow-up: 79 with asthmatic cough (cough variant asthma or eosinophilic bronchitis) and 201 with RCC. Baseline CHQ scores were similar between the groups (8.3±3.7 in asthmatic coughversus8.9±3.9 in RCC; p=0.215, adjusted for age, sex and and LCQ score). There were no significant between-group differences in the LCQ and cough severity VAS scores. Both groups showed a similar negative correlation with LCQ scores (asthmatic cough: r=−0.427, p<0.001; RUCC: r=−0.306, p<0.001).The symptoms of cough hypersensitivity may not distinguish between asthmatic cough and RCC. This suggests that chronic cough is the primary diagnosis in both phenotypes. It indicates a shared mechanism in their cough pathogenesis, despite having potentially different treatable traits.
咳嗽超敏症状谱能否区分慢性咳嗽的表型?
咳嗽反射过敏的症状并不能区分哮喘性咳嗽和难治性慢性咳嗽。最近,咳嗽反射过敏症被认为是成人慢性咳嗽的一个共同基本特征。然而,人们尚未对不同表型慢性咳嗽的咳嗽反射过敏症状和临床特征进行研究。本研究旨在比较哮喘性慢性咳嗽患者和难治性慢性咳嗽(RCC)患者咳嗽过敏的症状特征,如咳嗽诱因和相关咽喉感觉。医生在 6 个月的随访中根据临床评估和治疗反应确定病因诊断。分析包括完成随访的 280 名患者:79 名哮喘性咳嗽(咳嗽变异性哮喘或嗜酸性粒细胞性支气管炎)患者和 201 名 RCC 患者。两组患者的基线 CHQ 评分相似(哮喘咳嗽患者为 8.3±3.7,RCC 患者为 8.9±3.9;经年龄、性别和 LCQ 评分调整后,P=0.215)。LCQ 和咳嗽严重程度 VAS 评分在组间无明显差异。两组患者的 LCQ 评分均呈相似的负相关(哮喘性咳嗽:r=-0.427,p<0.001;RUCC:r=-0.306,p<0.001)。这表明慢性咳嗽是这两种表型的主要诊断依据。这表明,尽管这两种表型可能具有不同的可治疗性,但它们的咳嗽发病机制是相同的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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