The occurrence of potential pathogenic antibiotic-resistant bacteria in the marine environment in Ha Long Bay, Vietnam

Nguyen Quang Huy, Pham Quynh Trang, Nguyen Thi Loi
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Abstract

This study aimed to investigate the occurrence of potential pathogenic bacteria from surface water samples collected at 30 stations along Ha Long Bay, Vietnam. Among 116 bacterial isolates identified, the composition analysis indicated 24 distinct bacterial genera, with Vibrio (29.3%), Pseudomonas (23.3%), Staphylococcus (8.6%), and Bacillus (6.0%) being the most dominant. The taxonomic analysis revealed 61/116 (52.6%) isolates as potential pathogens (risk group 2) belonging to 21 bacterial species. Potential pathogens were detected in 28/30 (93.3%) sampling stations, with the most common pathogens including Vibrio alginolyticus (n=25), Vibrioparahaemolyticus (n=5),Enterobacter cloacae (n=3), Pseudomonas mendocina (n=3), Aeromonas hydrophila (n=2), Enterobacter asburiae (n=2), Klebsiella oxytoca (n=2), Bacillus cereus (n=2),and Staphylococcus haemolyticus (n=2). The selected pathogens were highly resistant to Amoxicillin (100%), Piperacillin (100%), Amoxicillin + Clavulanate (85.7%), Ticarcillin (71.4%), Cefoxitin (54.4%), Kanamycin (50%), and Fosfomycin (50%), and less resistant to Trimethoprim + sulfamethoxazole, Fusidic Acid, Tetracycline, Erythromycin, Pristinamycin, Dalacin, and Rifampicin (<25%), and susceptible to the remaining antibiotics. Notably, 12/23 (52.2%) isolates were resistant to at least three antibiotics and were multidrug-resistant bacteria. Our findings underline that the occurrence of pathogenic antibiotic-resistant bacteria in the marine environment of Ha Long Bay presents a potential threat to human health. Further genomic surveillance studies are necessary to manage and control the emergence and spread of pathogenic-resistant bacteria in this area.
越南下龙湾海洋环境中潜在的致病性抗生素耐药菌的出现
本研究旨在调查从越南下龙湾沿岸 30 个站点采集的地表水样本中可能存在的致病细菌。在鉴定出的 116 个细菌分离物中,成分分析表明有 24 个不同的细菌属,其中弧菌(29.3%)、假单胞菌(23.3%)、葡萄球菌(8.6%)和芽孢杆菌(6.0%)是最主要的细菌属。分类分析显示,61/116(52.6%)个分离物为潜在病原体(风险组 2),属于 21 个细菌种类。28/30(93.3%)个采样站检测到潜在病原体。最常见的病原体包括溶藻弧菌(25 个)、溶血性弧菌(5 个)、肠杆菌(3 个)、藻溶血性弧菌(25 个)、溶血性弧菌(5 个)、泄殖腔肠杆菌(3 个)、门冬酰胺假单胞菌(3 个)、嗜水气单胞菌(2 个)、阿斯布氏肠杆菌(2 个)、氧乐菌(2 个)、蜡样芽孢杆菌(2 个)和溶血性葡萄球菌(2 个)。所选病原体对阿莫西林(100%)、哌拉西林(100%)、阿莫西林+克拉维酸(85.7%)、替卡西林(71.4%)、头孢西丁(54.4%)、卡那霉素(50%)和磷霉素(50%),对甲氨蝶呤+磺胺甲噁唑、夫西地酸、四环素、红霉素、普里什霉素、达拉嗪和利福平(<25%)的耐药性较低,对其余抗生素易感。值得注意的是,12/23(52.2%)株分离菌至少对三种抗生素产生耐药性,属于多重耐药菌。我们的研究结果表明,下龙湾海洋环境中出现的致病性耐抗生素细菌对人类健康构成了潜在威胁。有必要开展进一步的基因组监测研究,以管理和控制耐病原菌在该地区的出现和传播。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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