Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2024-06-17 DOI:10.1007/s12105-024-01635-4

Esraa Ashraf Mahmoud, Mohsen Kazem Abdellatif, Sarah Ahmed Mohammed Mahmoud

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引用次数: 0

Abstract

Purpose: The aim of the study is to investigate the immunohistochemical expression of both Alpha smooth muscle actin and Transforming Growth Factor beta and compare their expression in oral papillary squamous cell carcinoma with their expression in different histological grades of oral squamous cell carcinoma. A correlation between these immuno-histochemical expressions and histological findings will then be performed. The research question is "Do the percentages of α-SMA and TGF-β immune-expression in OPSCC differ from that in the conventional OSCC?".

Methods: This will be achieved by collecting archival blocks of oral papillary squamous cell carcinoma and different grades of oral squamous cell carcinoma, staining the specimens with Transforming Growth Factor beta and alpha smooth muscle actin, then measuring the mean staining index of expression in each group and the area percent of both markers.

Results: Results revealed that transforming growth factor beta expression in the epithelium was high in all cases of well-differentiated squamous cell carcinoma, most oral papillary squamous cell carcinoma, and poorly differentiated oral squamous cell carcinoma. On the other hand, different grades of oral squamous cell carcinoma showed a high staining index of alpha smooth muscle actin expression in the stroma. While cases of oral papillary squamous cell carcinoma were either moderate or low-staining.

Conclusions: Oral papillary squamous cell carcinoma has a favourable prognosis compared to different histological grades, and the prognosis does not depend only on histological grade but also on other prognostic factors.

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口腔乳头状鳞状细胞癌和口腔鳞状细胞癌：组织病理学和免疫组化比较研究》（Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study）。

目的：本研究旨在调查阿尔法平滑肌肌动蛋白和转化生长因子β的免疫组化表达，并将它们在口腔乳头状鳞状细胞癌中的表达与它们在不同组织学级别的口腔鳞状细胞癌中的表达进行比较。然后将进行这些免疫组织化学表达与组织学结果之间的相关性分析。研究问题是 "OPSCC 中 α-SMA 和 TGF-β 免疫表达的百分比与传统 OSCC 中的百分比是否不同？方法：通过收集口腔乳头状鳞状细胞癌和不同等级口腔鳞状细胞癌的档案块，用转化生长因子β和α平滑肌肌动蛋白对标本进行染色，然后测量各组表达的平均染色指数和两种标记物的面积百分比：结果发现，在所有分化良好的鳞状细胞癌、大多数口腔乳头状鳞状细胞癌和分化不良的口腔鳞状细胞癌中，上皮细胞中转化生长因子β的表达量都很高。另一方面，不同等级的口腔鳞状细胞癌基质中α平滑肌肌动蛋白的染色指数较高。结论：结论：与不同组织学分级相比，口腔乳头状鳞状细胞癌的预后较好，其预后不仅取决于组织学分级，还取决于其他预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.