Brain metastasis originating from papillary renal cell carcinoma: A rare case report and literature review

Abstract

Papillary Renal Cell Carcinoma (PRCC) being the second most common histological type of Renal Cell Carcinoma (RCC). Although brain metastasis is rare in RCC, it often results in poorer outcomes compared to metastases in other locations. We present a case of brain metastasis originating from PRCC classified as pT1bN0M1. Subsequently, the patient underwent successful cytoreductive nephrectomy and pazopanib therapy as a follow-up systematic treatment. This case highlights the importance of urologists being aware of brain metastases that can develop in PRCC patients, which typically have a poorer outcome.