Desensitization Strategies for Donor-Specific Antibodies in HLA-Mismatched Stem Cell Transplantation Recipients: What We Know and What We Do Not Know.

IF 3.2 Q2 ONCOLOGY

Oncology and Therapy Pub Date : 2024-09-01 Epub Date: 2024-06-15 DOI:10.1007/s40487-024-00283-6

Yang Zhou, Yu-Lun Chen, Xi-Yi Huang, Ying-Jun Chang

引用次数: 0

Abstract

In human leukocyte antigen (HLA)-mismatched allogeneic stem cell transplantation settings, donor-specific anti-HLA antibodies (DSAs) can independently lead to graft failure, including both primary graft rejection and primary poor graft function. Although several strategies, such as plasma exchange, intravenous immunoglobulin, rituximab, and bortezomib, have been used for DSA desensitization, the effectiveness of desensitization and transplantation outcomes in some patients remain unsatisfactory. In this review, we summarized recent research on the prevalence of anti-HLA antibodies and the underlying mechanism of DSAs in the pathogenesis of graft failure. We mainly focused on desensitization strategies for DSAs, especially novel methods that are being investigated in the preclinical stage and those with promising outcomes after preliminary clinical application.

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针对 HLA 不匹配干细胞移植受者的捐献者特异性抗体的脱敏策略：我们知道什么，我们不知道什么。

在人类白细胞抗原（HLA）不匹配的异体干细胞移植中，供体特异性抗HLA抗体（DSA）可单独导致移植失败，包括原发性移植排斥反应和原发性移植功能低下。尽管已有多种策略用于DSA脱敏，如血浆置换、静脉注射免疫球蛋白、利妥昔单抗和硼替佐米，但脱敏效果和部分患者的移植结果仍不尽如人意。在这篇综述中，我们总结了近期关于抗 HLA 抗体的流行以及 DSA 在移植失败发病机制中的潜在机制的研究。我们主要关注DSAs的脱敏策略，尤其是正在临床前阶段研究的新型方法和初步临床应用后取得良好效果的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology and Therapy ONCOLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Now indexed in PubMed Aims and Scope Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. 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