Association of Sarcopenia and Oxygen Uptake Efficiency Slope in Male Patients With Heart Failure.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiopulmonary Rehabilitation and Prevention Pub Date : 2024-07-01 Epub Date: 2024-06-07 DOI:10.1097/HCR.0000000000000872

Henrique Nunes Bispo, Eduardo Rondon, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Marcel José Andrade da Costa, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Brian P Carson, Maria-Janieire de Nazaré Nunes Alves, Guilherme Wesley Peixoto da Fonseca

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引用次数: 0

Abstract

Purpose: Sarcopenia, the loss of muscle mass and function, is a common comorbidity in patients with heart failure (HF). The skeletal muscle modulates the respiratory response during exercise. However, whether ventilatory behavior is affected by sarcopenia is still unknown.

Methods: We enrolled 169 male patients with HF. Muscle strength was measured by a handgrip dynamometer. Body composition was measured with dual-energy X-ray absorptiometry. Sarcopenia was defined by handgrip strength <27 kg and appendicular lean mass divided by height squared (ALM/height 2 ) <7.0 kg/m 2 . Oxygen uptake efficiency slope (OUES), ventilation (VE), oxygen uptake (VO 2 ), and carbon dioxide output (VCO 2 ) were measured by a cardiopulmonary exercise test.

Results: Sarcopenia was identified in 29 patients (17%). At the first ventilatory threshold, VE/VO 2 (36.9 ± 5.9 vs 32.7 ± 6.5; P = .003) and VE/VCO 2 (39.8 ± 7.2 vs 35.3 ± 6.9; P = .004) were higher in patients with sarcopenia compared to those without sarcopenia. At the exercise peak, compared to patients without sarcopenia, patients with sarcopenia had lower OUES (1186 ± 295 vs 1634 ± 564; P < .001), relative VO 2 (16.2 ± 5.0 vs 19.5 ± 6.5 mL/kg/min; P = .01), and VE (47.3 ± 10.1 vs 63.0 ± 18.2 L/min; P < .0001), while VE/VCO 2 (42.9 ± 8.9 vs 38.7 ± 8.4; P = .025) was increased. OUES was positively correlated with ALM/height 2 ( r = 0.36; P < .0001) and handgrip strength ( r = 0.31; P < .001). Hemoglobin (OR = 1.149; 95% CI, 0.842-1.570; P = .038), ALM/height 2 (OR = 2.166; 95% CI, 1.338-3.504; P = .002), and VO 2peak (OR = 1.377; 95% CI, 1.218-1.557; P < .001) were independently associated with OUES adjusted by cofounders.

Conclusions: Our results suggest that sarcopenia is related to impaired ventilatory response during exercise in patients with HF.

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男性心力衰竭患者的肌肉疏松症与摄氧量效率斜率的关系

目的：肌肉减少症是心力衰竭（HF）患者常见的并发症，是指肌肉质量和功能的丧失。骨骼肌可调节运动时的呼吸反应。然而，呼吸行为是否会受到肌肉疏松症的影响仍是未知数：我们招募了 169 名男性心力衰竭患者。方法：我们招募了 169 名男性高血压患者，用手握式测力计测量肌肉力量。用双能量 X 光吸收测量法测量身体成分。以手握力量定义肌肉疏松症：发现 29 名患者（17%）患有肌肉疏松症。在第一个通气阈值时，肌肉疏松症患者的 VE/VO2 (36.9 ± 5.9 vs 32.7 ± 6.5; P = .003) 和 VE/VCO2 (39.8 ± 7.2 vs 35.3 ± 6.9; P = .004) 均高于无肌肉疏松症患者。在运动高峰期，与肌肉疏松症患者相比，肌肉疏松症患者的 OUES 更低（1186 ± 295 vs 1634 ± 564；P 结论：肌肉疏松症患者的 OUES 更低（1186 ± 295 vs 1634 ± 564；P = .004）：我们的研究结果表明，肌肉疏松症与心房颤动患者运动时通气反应受损有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiopulmonary Rehabilitation and Prevention 医学-心血管系统

CiteScore

5.40

自引率

34.20%

发文量

164

审稿时长

6-12 weeks

期刊介绍： JCRP was the first, and remains the only, professional journal dedicated to improving multidisciplinary clinical practice and expanding research evidence specific to both cardiovascular and pulmonary rehabilitation. This includes exercise testing and prescription, behavioral medicine, and cardiopulmonary risk factor management. In 2007, JCRP expanded its scope to include primary prevention of cardiovascular and pulmonary diseases. JCRP publishes scientific and clinical peer-reviewed Original Investigations, Reviews, and Brief or Case Reports focused on the causes, prevention, and treatment of individuals with cardiovascular or pulmonary diseases in both a print and online-only format. Editorial features include Editorials, Invited Commentaries, Literature Updates, and Clinically-relevant Topical Updates. JCRP is the official Journal of the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation.