Association of Sarcopenia and Oxygen Uptake Efficiency Slope in Male Patients With Heart Failure.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-07-01 Epub Date: 2024-06-07 DOI:10.1097/HCR.0000000000000872
Henrique Nunes Bispo, Eduardo Rondon, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Marcel José Andrade da Costa, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Brian P Carson, Maria-Janieire de Nazaré Nunes Alves, Guilherme Wesley Peixoto da Fonseca
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引用次数: 0

Abstract

Purpose: Sarcopenia, the loss of muscle mass and function, is a common comorbidity in patients with heart failure (HF). The skeletal muscle modulates the respiratory response during exercise. However, whether ventilatory behavior is affected by sarcopenia is still unknown.

Methods: We enrolled 169 male patients with HF. Muscle strength was measured by a handgrip dynamometer. Body composition was measured with dual-energy X-ray absorptiometry. Sarcopenia was defined by handgrip strength <27 kg and appendicular lean mass divided by height squared (ALM/height 2 ) <7.0 kg/m 2 . Oxygen uptake efficiency slope (OUES), ventilation (VE), oxygen uptake (VO 2 ), and carbon dioxide output (VCO 2 ) were measured by a cardiopulmonary exercise test.

Results: Sarcopenia was identified in 29 patients (17%). At the first ventilatory threshold, VE/VO 2 (36.9 ± 5.9 vs 32.7 ± 6.5; P = .003) and VE/VCO 2 (39.8 ± 7.2 vs 35.3 ± 6.9; P = .004) were higher in patients with sarcopenia compared to those without sarcopenia. At the exercise peak, compared to patients without sarcopenia, patients with sarcopenia had lower OUES (1186 ± 295 vs 1634 ± 564; P < .001), relative VO 2 (16.2 ± 5.0 vs 19.5 ± 6.5 mL/kg/min; P = .01), and VE (47.3 ± 10.1 vs 63.0 ± 18.2 L/min; P < .0001), while VE/VCO 2 (42.9 ± 8.9 vs 38.7 ± 8.4; P = .025) was increased. OUES was positively correlated with ALM/height 2 ( r = 0.36; P < .0001) and handgrip strength ( r = 0.31; P < .001). Hemoglobin (OR = 1.149; 95% CI, 0.842-1.570; P = .038), ALM/height 2 (OR = 2.166; 95% CI, 1.338-3.504; P = .002), and VO 2peak (OR = 1.377; 95% CI, 1.218-1.557; P < .001) were independently associated with OUES adjusted by cofounders.

Conclusions: Our results suggest that sarcopenia is related to impaired ventilatory response during exercise in patients with HF.

男性心力衰竭患者的肌肉疏松症与摄氧量效率斜率的关系
目的:肌肉减少症是心力衰竭(HF)患者常见的并发症,是指肌肉质量和功能的丧失。骨骼肌可调节运动时的呼吸反应。然而,呼吸行为是否会受到肌肉疏松症的影响仍是未知数:我们招募了 169 名男性心力衰竭患者。方法:我们招募了 169 名男性高血压患者,用手握式测力计测量肌肉力量。用双能量 X 光吸收测量法测量身体成分。以手握力量定义肌肉疏松症:发现 29 名患者(17%)患有肌肉疏松症。在第一个通气阈值时,肌肉疏松症患者的 VE/VO2 (36.9 ± 5.9 vs 32.7 ± 6.5; P = .003) 和 VE/VCO2 (39.8 ± 7.2 vs 35.3 ± 6.9; P = .004) 均高于无肌肉疏松症患者。在运动高峰期,与肌肉疏松症患者相比,肌肉疏松症患者的 OUES 更低(1186 ± 295 vs 1634 ± 564;P 结论:肌肉疏松症患者的 OUES 更低(1186 ± 295 vs 1634 ± 564;P = .004):我们的研究结果表明,肌肉疏松症与心房颤动患者运动时通气反应受损有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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